HETEROCYCLIC ANALOGS OF PLEIADIENE. 48. PYROSULFITE AS A MILD DEHYDROGENATING AGENT IN THE 2,3-DIHYDROPERIMIDINE SERIES. SYNTHESIS OF 2-POLYHYDROXYALKYLPERIMIDINES

Article abstract of DOI:10.1007/BF00475399

2,3-Dihydroperimidines are dehydrogenated smoothly by sodium pyrosulfite in refluxing aqueous alcohol, as a result of which the corresponding perimidines are formed in high yields.The reaction of 1,8-naphthalenediamine with the aldehydic forms of sugars gives 2-polyhydroxyalkyl-2,3-dihydroperimidines, which are also aromatized by sodium pyrosulfite to give the corresponding 2-polyhydroxyalkylperimidines in high yields.