Synthesis and antibacterial activity of a novel series of DNA gyrase inhibitors: 5-[(E)-2-arylvinyl]pyrazoles

DOI: 10.1016/j.bmcl.2005.06.103

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Bioorganic and Medicinal Chemistry Letters p. 4299 - 4303 (2005)

Update date:2022-08-04

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Authors:

Tanitame, Akihiko

Oyamada, Yoshihiro

Ofuji, Keiko

Terauchi, Hideo

Kawasaki, Motoji

Wachi, Masaaki

Yamagishi, Jun-Ichi

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Article abstract of DOI:10.1016/j.bmcl.2005.06.103

The 2-arylvinyl moiety in 1-(3-chlorophenyl)-3-(4-piperidyl)-5-[(E)-2-(5- chloro-1H-indol-3-yl)vinyl]pyrazole 2, which has previously shown improved DNA gyrase inhibition and target-related antibacterial activity, was transformed to other groups and the i

Full text of DOI:10.1016/j.bmcl.2005.06.103

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