SYNTHESIS OF A CHIRAL 1,1,3-TRIMETHYLCYCLOHEXANE DERIVATIVE FROM d-CAMPHOR: A POTENT KEY BUILDING BLOCK FOR ENT-TAXANE-TYPE DITERPENOIDS

Article abstract of DOI:10.1246/cl.1980.1001

A chiral 1,1,3-trimethylcyclohexane derivative (12), which is a potent key building block for synthesis of ent-taxane-type diterpenoids, has been prepared from d-camphor (2) through a conversion pathway which involves a novel ring enlargement reaction of a 1,1,2-trimethylcyclopentane derivative (3).