Journal of Organic Chemistry p. 2883 - 2887 (1980)
Update date:2022-08-04
Topics: Preparation
Middleton, W. J.
Bingham, E. M.
Several α,α-difluoroarylacetic acids have been prepared by reaction of DAST ((diethylamino)sulfur trifluoride) with esters of α-oxoarylacetic acids and then hydrolysis of the resulting difluoro ester.Examples include the α,α-difluoro derivates of the synthetic plant auxin, α-naphthylacetic acid, and the antiinflammatory drug, ibufenac.
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