Bioorganic and Medicinal Chemistry Letters p. 3753 - 3755 (2004)
Update date:2022-08-04
Topics:
Tan, Qiang
Birzin, Elizabeth T.
Chan, Wanda
Yang, Yi Tien
Pai, Lee-Yuh
Hayes, Edward C.
Dasilva, Carolyn A.
Dininno, Frank
Rohrer, Susan P.
Schaeffer, James M.
Hammond, Milton L.
Dihydrobenzodithiin compounds (1-6) were prepared to explore the expansion of the dihydrobenzoxathiin lead compounds I-III as SERAMs (Selective Estrogen Receptor Alpha Modulators). The dihydrobenzodithiin compounds generally maintained a high degree of selectivity for ERα over ERβ, however, they lacked the in vivo antagonism/agonism activity exhibited by the lead class in an immature rat uterine growth model.
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