Perfluoro allyl fluorosulfate (FAFS): A versatile building block for new fluoroallylic compounds

Article abstract of DOI:10.3390/molecules16086512

In this study we will present and discuss both the synthesis of CF ₂=CFCF₂OSO₂F (perfluoroallyl fluorosulfate, FAFS), focusing in particular on the important role of C₃F ₆/SO₃ ratio, reaction temperature and boron catalyst/SO₃ ratio on FAFS' yield and selectivity, as well as a wide variety of ionic and radical reactions possible with FAFS. We focused our attention on reactions of FAFS with aliphatic and aromatic alcohols, acyl halides, halides, H₂O₂, ketones and radicals whose synthesis and reaction mechanisms will be presented and discussed. Particular attention will be devoted to the novel diallyl-fluoroalkyl peroxide obtained. Factors such as pKa and Lowry and Pearson's Hard/Soft Acid-Base Theory which determine the selectivity between Addition/Elimination vs. Nucleophilic Substitution reaction mechanisms on FAFS will also be presented and discussed.

Full text of DOI:10.3390/molecules16086512

Molecules 2011, 16, 6512-6540; doi:10.3390/molecules16086512
OPEN ACCESS
molecules
ISSN 1420-3049
www.mdpi.com/journal/molecules
Article
Perfluoro Allyl Fluorosulfate (FAFS): A Versatile Building
Block for New Fluoroallylic Compounds
Ivan Wlassics *, Vito Tortelli, Serena Carella, Cristiano Monzani and Giuseppe Marchionni
Solvay Solexis, Viale Lombardia, 20-Bollate, Milan 20021, Italy;
E-Mails: vito.tortelli@solvay.com (V.T.); serena.carella@solvay.com (S.C.);
cristiano.monzani@solvay.com (C.M.); giuseppe.marchionni@solvay.com(G.M.)
* Author to whom correspondence should be addressed; E-Mail: ivan.wlassics@solvay.com;
Tel.: +39-02-38356367; Fax: +39-02-38356355.
Received: 27 June 2011; in revised form: 22 July 2011 / Accepted: 29 July 2011 /
Published: 4 August 2011
Abstract: In this study we will present and discuss both the synthesis of
CF2=CFCF2OSO2F (perfluoroallyl fluorosulfate, FAFS), focusing in particular on the
important role of C3F6/SO3 ratio, reaction temperature and boron catalyst/SO3 ratio on
FAFS’ yield and selectivity, as well as a wide variety of ionic and radical reactions
possible with FAFS. We focused our attention on reactions of FAFS with aliphatic and
aromatic alcohols, acyl halides, halides, H2O2, ketones and radicals whose synthesis and
reaction mechanisms will be presented and discussed. Particular attention will be devoted
to the novel diallyl-fluoroalkyl peroxide obtained. Factors such as pKa and Lowry and
Pearson’s Hard/Soft Acid-Base Theory which determine the selectivity between
Addition/Elimination vs. Nucleophilic Substitution reaction mechanisms on FAFS will also
be presented and discussed.
Keywords: perfluoroallyl fluorosulfate; addition/elimination reactions; fluorinated allyl
ethers; perfluoro-diallyl peroxide; pKa
1. Introduction
Early literature studies of fluoro olefin reactions with sulfur trioxide (SO3) have shown that the
principal reaction of terminal fluoro olefins is a [2+2] cycloaddition to form sultones [1,2]. If the SO3
employed in the reaction with hexafluoropropene contains as low as 0.5 wt % of a boron-based catalyst

Molecules 2011, 16
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(sometimes used to stabilize commercial SO3: Sulfan®): BF3, B(OCH3)3, B2O3, then perfluoro allyl
fluorosulfate, CF2=CFCF2OSO2F (FAFS) is formed in modest to moderate yields (40%–60%) and
>60% selectivity with respect to the corresponding sultone [2-5] according to the boron-mediated
mechanism shown in Scheme 1.
Scheme 1. BF3 mediated synthesis of FAFS vs. synthetic route in the absence of BF3.
F
F
CF3CF=CF2
SO3
+
BF3cat
CF3
F
O
S
O
O
F
+
F
F
F
B
+
OSO2F
F
F
CF2=CFCF2OSO2F
Many different organic reactions can be carried out easily and with good yields with FAFS, namely
(a) addition/elimination reactions with nucleophiles on the terminal allylic double bond by taking
−
advantage both of FAFS’ FSO3 anion being a very good leaving group, and the fact that attack by
nucleophiles on sp3 carbon in highly fluorinated molecules does not occur [2]; (b) esterification on
FAFS’ sulfur atom due to its elevated electronegativity and being F− a good leaving group; (c) radical
reactions, for example with hypofluorites such as CF3OF and FSO2CF2CF2OF [6], taking advantage of
allylic resonance stabilization. Furthermore, Kostov and co-workers [7] have demonstrated that the
allylic monomers generated from FAFS can be copolymerized with tetrafluoroethylene suggesting that
FAFS’ derivatives can find useful applications in polymer chemistry.
The aim of the present work was to study various parameters concerning FAFS’ synthesis in order
to increase yield and selectivity, to study the parameters that govern Addition/Elimination vs.
Substitution at the sulfur atom, to synthesize and characterize a wide selection of fluoroallyl
compounds for possible applications in polymer chemistry.
2. Results and Discussion
2.1. Synthesis of FAFS
Perfluoroallyl fluorosulfate (FAFS) has been known since 1981 [2] and its synthesis involves
formally the insertion of SO3 in a C–F bond of hexafluoropropene (HFP) mediated by a boron
catalyst [3,4] shown in Scheme 1. To date, the literature reports very little regarding both the synthesis
and the utilization of FAFS as a source of perfluoroallyl-functionalities. In order to maximize FAFS’
yield and selectivity, we evaluated several parameters that might affect the outcome of the reaction:
• SO3/HFP molar ratio;
• Boron catalysts/SO3 molar ratio;
• SO3 concentration (oleum 20% (w/w) vs. oleum 65% (w/w) vs. 100% (distilled);
• Reaction temperature.

Molecules 2011, 16
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Figure 1 shows that there is a direct correlation between FAFS’ yield and the SO3/HFP ratio. The
reaction temperature was always 37 °C. Surprisingly, the highest yields of FAFS are obtained at
sub-stoichiometric ratios of SO3 with respect to the moles of HFP. The optimal molar SO3/HFP ratio
was found to be 0.5:1. The explanation is that, as reported in the literature [8], monomeric SO3 tends to
easily form dimers and trimers. Apparently, the dimerization and trimerization rate is faster than the
rate of SO3 insertion in HFP. The SO3 dimers and trimers are not reactive with boron catalysts and tend
to precipitate out of solution as inert solids thereby lowering FAFS’ yield. This effect is greatly
enhanced when approaching a 2/1 SO3/HFP molar yield.
Figure 1. FAFS yield as a function of SO3/HFP molar ratio at 37 °C.
80
70
67
65
60
54
50
40
32
30
20
13
10
0
0
0.2
0.4
0.6
0.8
1
1.2
1.4
1.6
1.8
2
SO3/HFP (mol/mol)
The boron-SO3 active catalyst complex shown in Scheme 1 can be achieved with several boron
derivatives as shown in Table 1. The best results in terms of yield and selectivity are obtained by
bubbling anhydrous BF3 in SO3 (100%) reaching a w/w BF3/SO3 ratio anywhere between 1.8 and 3.5
(Trial 4). In Trial 5 we tried to perform the synthesis with commercially available BF3*2 H2O simply
because, being a solution at room temperature and pressure, it is easier to handle than anhydrous BF3
which is contained in a pressurized cylinder. The high HFP sultone selectivity suggests that BF3*2
H2O doesn’t form the boron-SO3 catalyst complex effectively. The same holds true for B(OCH3)3
(Trial 6). The only boron derivative that performed comparably to anhydrous BF3 was commercially
available B2O3 (Trial 7) and can be considered a valid alternative to the more dangerous and difficult
to handle anhydrous BF3.
Table 2 shows that the boron-SO3 catalyst complex doesn’t form in the presence of sulfuric acid
(oleum at various SO3 concentrations) even at elevated BF3 w/w ratios vs. SO3. Unless pure, freshly
distilled SO3 is employed, the principal reaction product will always be the sultone.

Molecules 2011, 16
Table 1. FAFS selectivity and yield as a function of Boron catalyst type or born catalyst concentration.
6515
Boron
derivative
w/w vs. SO3 FAFS Selectivity PEP Sultone FAFS Yield
Trial
100%
0
(% mol)
<5
Sel. (% mol)
(%)
<5
50
55
65
48
15
45
1
2
3
4
5
6
7
anhydrous BF3
anhydrous BF3
anhydrous BF3
anhydrous BF3
BF3*2H2O
B(OCH3)3
>95
35
15
<5
52
57
20
0.5–1
1–1.6
18.–3.5
1.03
6
65
85
95
48
43
B2O3
4
80
Table 2. FAFS/HFP sultone molar selectivity as a function of [SO3].
Anhydrous BF3
(w/w vs. SO3)
FAFS/HFP sultone
Trial
SO3 type
(mol/mol)
1/99
8
20% Oleum
3
6
3
6
3
6
1/99
4/96
4/96
97/3
9
65% Oleum
100% SO3
10
95/5
Electrophilic ring opening of the HFP sultone described in the literature [9,10] will at most only
give CF3CF=CFOSO2F and, following SO3 insertion at the terminal C–F bond, FSO2–O–CF=CFCF2–
O–SO2F. Several attempts of such a ring opening were tried with no reaction even at high
concentrations of BF3 and at reaction temperatures of 40–60 °C.
Early work by Krespan [3] demonstrated that FAFS can insert a second equivalent of SO3,
obtaining FSO2OCF2CF=CFOSO2F, with the same mechanism as the first insertion of SO3 in HFP
shown in Scheme 1. This side reaction contributes not only to lower FAFS selectivity, but also FAFS
yield since it involves SO3 consumption. Data available from the literature [2,5] show that the reaction
temperature for the boron catalyzed SO3 insertion in HFP was 50–150 °C and with rather low FAFS
yields ranging from 20%–35%.
Table 3 shows the temperature dependence of FAFS’ selectivity employing the best reaction
conditions found thus far: Use of freshly distilled SO3 (b.p. = 43 °C), SO3/HFP molar ratio = 0.5/1,
anhydrous BF3 with BF3/SO3 w/w % =1.8. Along with the optimal reaction conditions just mentioned,
Table 3 shows that the best temperature for this reaction is <40 °C.
Table 3. FAFS and its side reaction products as a function of reaction temperature.
Trial T (°C)
FAFS/FSO2–O–CF2CF=CFO–SO2F/Sultone
11
12
13
37
60
100
95/4/1
35/60/5
20/75/5

Molecules 2011, 16
6516
2.2. FAFS Regiochemistry
FAFS is an asymmetrical olefin and therefore it will have two centers of attack about the CF2=CF–
bond: The C-3 terminal olefin carbon or the C-2 internal carbon. Furthermore, FAFS also embodies
two distinct electrophilic centers: The terminal olefin and the electrophilic sulfur atom as well. These
electronic features give FAFS a variety of different regiochemistries depending on the nature of
the reaction.
2.2.1. Radical reactions
As with all asymmetrical olefins [11] the attacking radical will add to the carbon center that will
generate the most stable radical intermediate, which in this case is the terminal C-3 carbon center. The
radical sum of a general hypofluorite ROF gave the product distributions and reaction mechanisms
shown in Scheme 3.
Scheme 3. FAFS regioselectivity with radicals employing a general hypofluorite ROF.
.
[
ROCF2CFCF2SO2F
]
ROCF2CF2CF2SO2F
a
70%
a
CF2=CFCF2OSO2F
ROF
+
b
.
[
CF CFCF SO F
2
]
2
2
CF3CFCF2SO2F
b
RO
RO
30%
The different molar product distribution reflects the relative stability of a primary vs. secondary
radical on a fluorinated carbon. The following hypofluorites were added to FAFS with moderate to
good yields: CF3OF, FSO2CF2CF2OF and CF2(OF)2.
2.2.2. Nucleophilic reactions
It will be shown that FAFS, due to its electrophilic nature, is quite reactive towards a number of
different nucleophiles, including for example alcohols, yielding the corresponding fluorinated allyl
ethers. Unlike what was previously reported in the literature [4], it is subject to nucleophilic
substitution by alcohols both without basic catalysis (i.e., directly with the protonated alcohol) as well
as with the corresponding conjugate base. Employing an excess of an alcohol in the presence of FAFS
one always obtains the corresponding allyl ether. Table 4 shows the selectivities and product
distributions of some typical hydrogenated and partially fluorinated alcohols both with (Na+ as the
cation) and without basic catalysis.
Of course, with the base catalyzed nucleophilic addition to FAFS, one must employ stoichiometric
quantities of the alcohol in order to avoid a second addition of the alcoholate to the allyl ether yielding,
from a general alcohol ROH, RO–CF2CFHCF2–OR. The proton in the fluorinated propyl chain comes
from the solvent (generally CH3CN or glymes) employed.

Molecules 2011, 16
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Table 4. FAFS regioselectivity with several oxygen nucleophiles.
Conv.
Trial Nucleophile
Products (selectivity %)
(FAFS)
100%
100%
54%
98%
46%
97%
96%
99%
30%
14
15
16
17
18
19
20
21
22
23
CH3OH
CH3ONa
C6H5OH
C6H5ONa
CF3CH2OH
CF3CH2ONa
C6H5CH2OH
C6H5CH2ONa
C6F5OH
CH3OCF2CF=CF2 (100%)
CH3OCF2CF=CF2 (100%)
C6H5OCF2CF=CF2 (86%)/CF2=CFCF2OSO2OC6H5 (14%)
C6H5OCF2CF=CF2 (87%)/CF2=CFCF2OSO2OC6H5 (13%)
CF3CH2OCF2CF=CF2 (85%)/CF2=CFCF2OSO2OCH2CF3 (15%)
CF3CH2OCF2CF=CF2 (86%)/CF2=CFCF2OSO2OCH2CF3 (14%)
C6H5CH2OCF2CF=CF2 (95%)/CF2=CFCF2OSO2OCH2C6H5 (5%)
C6H5CH2OCF2CF=CF2 (94%)/CF2=CFCF2OSO2OCH2C6H5 (6%)
C6F5OCF2CF=CF2 (86%)/CF2=CFCF2OSO2OC6F5 (14%)
C6F5OCF2CF=CF2 (90%)/CF2=CFCF2OSO2OC6F5 (10%)
C6F5ONa
100%
Table 4 shows that there are at least two distinct regiochemistries involved in the nucleophilic
addition to FAFS: One yields an allyl ether (main product) and the other a sulfate ester (minor product).
Scheme 4 shows the three possible sites of attack of a general nucleophile to FAFS. Taking reaction
1 depicted in Scheme 4 into consideration, unlike the hypofluorite radical addition shown in Scheme 3,
nucleophilic attack was almost exclusively (>98.5/1.5) observed on the terminal olefin yielding a
secondary anion. Pathway 1 is an Addition/Elimination (A/E) mechanism of the nucleophile to FAFS’
−
terminal double bond. The main driving force of the reaction is the powerful leaving group FSO3 .
Furthermore, it is known from the literature that attack by a nucleophile on the sp3 carbon in highly
fluorinated molecules does not occur [2]. On the other hand, Pathway 2 is a Substitution (SN) reaction
by the nucleophile on FAFS’ sulfur atom yielding a sulfate ester. The driving force of this reaction is
the electropositive sulfur and the relatively good leaving group, F−. In very few instances and with
particularly acidic fluoro alcohols, Pathway 3 was also observed: Once FSO3M (M = H, Metal) is
formed by Pathway 1, a second nucleophile can attack FSO3M’s electropositive sulfur atom, displace
F− and form the general product NuOSO2M.
As can be seen from Table 5 there is a direct correlation between the alcohol’s pKa and the A/E vs.
SN product distribution shown in Table 4.
Scheme 4. Different modes of nucleophilic attack of a general nucleophile Nu: on FAFS.

Molecules 2011, 16
Table 5. Correlation between an oxygen nucleophile’s pKa and substitution selectivity on FAFS.
6518
ROH
C6H5OH
CF3CH2OH
C6H5CH2OH
CH3OH
pKa
9,9
12,4
15
CF2=CFCF2OSO2OR %
14
15
5
16
0
Alcohols with a pKa less than 13 and therefore relatively “acidic” either by resonance effect (as in
phenol, pKa = 9.9) or by inductive effect (as in trifluoroethanol, pKa = 12.4) give a higher percentage
of SN product (Pathway 2). On the other hand, methanol (pKa = 16) and benzyl alcohol (pKa = 15),
which are more basic, give almost exclusively the A/E product (Pathway 1).
Another interesting feature that emerges from the data presented in Table 4 is that the A/E vs. SN
selectivity remains practically unchanged regardless to whether the nucleophile is a charged species
(oxyanion) or a species with a free unpaired electron doublet on the oxygen atom (alcohol). This leads
us to assert that the regioselectivity observed is determined not only by the particular electronic nature
of the nucleophile (pKa due to resonance or inductive effects, oxyanion vs. protonated alcohol) but also
on the electronic nature of FAFS’s terminal olefin vs. FAFS’s sulfur atom.
Finally, regardless of the regiochemistry observed, the base catalyzed addition of an alcohol to
FAFS is a much faster reaction as evidenced by the higher conversions of FAFS with the conjugate
base vs. the free alcohol. The striking differences in regioselectivities observed thus far, led us to
investigate if there was a “cation” effect on regioselectivity as well. It is known in the literature that the
electronic nature of the nucleophiles is not only governed by inductive and mesomeric effects, but also
by the Hard-Soft-Acid-Base theory of Lewis [12] and Pearson [13] whose trends are shown in Figure 2.
Figure 2. Lewis [12] and Pearson’s [13] representation of the “Hard-Soft-Acid-Base
theory concerning anions and cations.
It becomes clear that, based on the regiochemistry considerations made thus far, varying the
nucleophile’s cation may vary the regiochemistry for the nucleophilic attack on FAFS.

Molecules 2011, 16
6519
We therefore used pentafluorophenol (pKa = 8.9) [14] as a model compound to study the effects
of Ca2+, K+ and Na+ cations on regiochemistry. The averaged results of the cation effect on
regiochemistry are shown in Table 6 along with the 19F-NMR details shown in Figures 3a–c. All
reactions were performed in anhydrous THF with a stoichiometric quantity of nucleophiles with
respect to the moles of FAFS.
Table 6. Addition/Elimination vs. Substitution molar selectivities on FAFS as a function of the cation.
Trial
24
25
Nucleophile TR(°C)
C6F5OCF2CF=CF2/C6F5O–SO2–OCF2CF=CF2
(C6F5O)2Ca
C6F5OK
40 °C
40 °C
40 °C
13/87
60/40
90/10
26
C6F5ONa
Figure 3. 19F-NMR (200 MHz) spectrum of the Addition/Elimination (“Allyl”) vs.
Substitution (“Ester”) products after reaction between FAFS and (a) C6F5ONa, (b) C6F5OK
and (c) (C6F5O)2Ca.
(a)

Molecules 2011, 16
6520
Figure 3. Cont.
(b)
(c)

Molecules 2011, 16
6521
The experimental data reported in Table 6 confirm the HSAB theory summarized in Figure 3: In
going from a Na+ cation to a Ca2+ cation the hard base alcoholate becomes progressively more
ionically charged or, in other words, less covalently bound, and therefore more susceptible to attacking
FAFS’ very electropositive sulfur atom. Therefore, the main product of the nucleophilic addition of
sodium perfluoro phenolate and FAFS is C6F5OCF2CF=CF2 (A/E selectivity = 90%), the minor
product is CF2=CFCF2OSO3C6F5 (SN selectivity = 10%); on the other hand, the main product
employing calcium phenolate is the sulfate ester (SN selectivity = 87%), and the minor product is the
corresponding perfluoro allyl ether (A/E; selectivity= 13%). Pure compounds from Trials 24 and 26
were isolated by flash silica gel chromatography and identified by GC-MS. This permitted us to
unequivocally assign the 19F-NMR frequencies (in ppm) observed in Figures 3a–c and shown in Table 7.
Table 7. Specific 19F-NMR (300 MHz) frequencies observed for Addition/Elimination (a–c’)
vs. Substitution (d–f’) products.
a
b
c
c’
d
-
e
-
f
-
f’
-
b
–OaCF2 CF=c,c’CF2
−70.6 −189 −89.8 −103.2
–OSO2O-dCF2 CF=f,f’CF2
-
-
-
-
−71.2 −189.5 −94.2 −105.8
e
Therefore, in a base catalyzed addition between an alcohol’s conjugate base and FAFS, in order to
selectively obtain an A/E product, i.e., an allyl ether as the main product, the cation must be Na+.
One of the few well documented A/E reactions in the literature is the sum of a metal halide MX, to
FAFS where X = I, Br, Cl [4]. It becomes immediately obvious that ICF2CF=CF2 is a hydrolytically
stable synthon of FAFS, but with only one possible regioisomer obtainable due to the absence of the
electrophilic sulfur atom. Therefore, if quantitative selectivity towards A/E is necessary, ICF2CF=CF2
can be synthesized in situ (see Experimental), according to a slightly modified reaction procedure with
respect to the literature [4], and immediately added to the nucleophile according to Scheme 5.
Complete regioselectivity towards the allyl ether is obtained with isolated yields ranging from
55%–85% depending upon the alcohol.
Scheme 5. Allyl iodide mediated synthesis of allyl ethers.
OH
OCF2CF=CF2
CH3CN
DMF
R
/H2O/Et2O
FSO3K
KI
ICF2CF=CF2
+
CF2=CFCF2OSO2F
+
KOH
R
2.3. Addition/Elimination Reactions with FAFS
FAFS is a very versatile monomer and can be employed in a wide variety of nucleophilic reactions
obtaining, according to the rules and mechanisms just discussed, a plethora of allylic derivatives.
Scheme 6 summarizes some of these derivatives in a general manner.

Molecules 2011, 16
6522
Scheme 6. Generalized product library possible with FAFS.
O
CF2=CFCF2OOCF2CF=CF2
RCF(OCF2CF=CF2)R'
H2O2
RCR'
OCF2CF=CF2
NO2
OCF2CF=CF2
F
F
F
ArOH
ROH
CF2=CFCF2OSO2F
ROCF2CF=CF2
;
F
NO2
MX
F
R COF
f
NaN3
XCF2CF=CF2
R
CF2OCF2CF=CF2
f
CF2=CFCF2N3
2.3.1. Aromatic and aliphatic alcohols
Table 8 summarizes some specific examples of A/E of aliphatic and aromatic alcohols, both
hydrogenated and partially fluorinated. As can be observed, with the exception of methanol and benzyl
alcohol, all other alcohols and phenols have a pKa < 13 and therefore need a basic catalysis and Na+ as
the counter cation in order to have both good conversions of FAFS and especially a high selectivity
towards A/E, as previously described.
Table 8. Reaction selectivities and Addition/Elimination yields for the addition of several
aliphatic and aromatic alcohols with different pKa to FAFS.
ROH
CH3OH
C6H5CH2OH
CF3CH2ONa
C6H5ONa
pKa
16
15
12.4
9.9
9.5
8.9
7.2
4
Sel. (%)
99%
95%
85%
86%
92%
90%
90%
85%
A/E Isolated Yield
80%
50%
65%
87%
48%
60%
75%
55%
3-CF3-Ph-ONa
C6F5ONa
4-NO2-Ph-ONa
2,4-NO2-Ph-ONa
We observed that the best solvents for all of the reactions were aprotic ones such as anhydrous
CH3CN or THF. In these solvents FSO3Na, the elimination product, is practically insoluble; this
physical-chemical condition helps push the reaction to the right favoring high FAFS conversions and
minimizing the side reaction of Pathway 3, shown in Scheme 4. In some instances diglyme proved to
be a good solvent due to its excellent solvation properties. Care must be taken if employing diglyme:
If the reaction pH drops, FSO3H is a strong enough acid to protonate diglyme yielding inverse
Williamson [15] degradation products which react with FAFS, lowering the reaction yield. The
isolated yield of the allyl ethers shown varies depending on the specific substrate.
As shown in Table 8 most of the Nucleophilic A/E reactions were performed with basic catalysis; it
was therefore preferable to operate in substoichiometric amounts of the nucleophiles in order to avoid
the side reaction shown in Scheme 7.

Molecules 2011, 16
Scheme 7. Main side reaction product if excess nucleophile is employed in the in the
6523
base-promoted addition of an alcohol to FAFS.
O-Na+
OCF2CF=CF2
OCF2CFHCF2O
H+
+
R
R
R
R
For this reason diglyme was often chosen as the solvent since it effectively solubilizes many sodium
conjugate bases of alcohols. In this way it is possible to add the dissolved nucleophile to FAFS
keeping it in molar defect with respect to the allyl ether reaction product. The necessary proton for
protonation of the intermediate fluorinated carbanion can come from traces of H2O or the solvent
itself. Electron withdrawing substituents on the aromatic ring such as F–, CF3–, NO2– simply
contribute to lowering the pKa of the phenol, but have no noticeable effects on A/E vs. SN selectivity.
The rules that govern the regioselectivity of a nucleophile described in the previous section are
therefore obeyed.
2.3.2. Acyl fluorides
Acyl fluorides having the general formula RfCOF, placed with a stoichiometric amount of a metal
fluoride MF (M = Na, K, Cs), react with FAFS yielding a perfluoroallyl alkyl ether as shown in
Scheme 8.
Scheme 8. Generalized reaction scheme for the addition of a fluorinated acyl fluoride to FAFS.
Rf may be either F− or a perfluorinated alkyl chain of any length. Perfluoroallyl alkyl ethers have
already been synthesized by Krespan [16] and employed in polymerization reactions with fluorinated
olefins [17,18]. The reported literature yields were rather low; we therefore evaluated parameters such
as reaction temperature, solvent and reaction pressure in order to try to improve Krespan’s yields and
selectivities.
The rate-determining step is the acyl fluoride <==> alcoholate equilibrium. The alcoholate, due to
the inductive effect of –CF2– α to the oxyanion is less nucleophilic than its hydrogenated counterpart.
It is furthermore known in the literature [19] that the equilibrium reaction in Scheme 8 is shifted to the
right with increasing reaction temperature.
Using CF3COF as a model acyl fluoride in the presence of anhydrous KF we found that the
maximum concentration of alcoholate, CF3CF2O−K+, was 70% obtained at 30 °C as determined by
19F-NMR (+22 ppm, sharp, for –COF vs. −18 ppm, broad, for –CF2O− with CFCl3 as an internal
standard). Unfortunately, performing the reaction with FAFS at this temperature yielded only
−
CF3CF=CF2 (HFP), SO2F2, FSO3 and CF2=CFCOF (ACF, traces). No perfluoroallyl ethers were detected.

Molecules 2011, 16
6524
The presence of ACF and SO2F2 indicated that there must have been a nucleophilic attack by F−
anion on FAFS’ sulfur atom; this reaction is shown in Scheme 9. The literature reports that catalytic
desulfurilation reactions such as this one generally occur at high reaction temperatures (>100 °C) but it is
plausible that it may also occur at much lower temperature with very reactive compounds such as FAFS.
Scheme 9. Desulfurilation of FAFS by F(−)—Reaction products.
O
F-
+
SO 2F2
SF
+
F-
C F2=C FC F2
O
C F2=C FC O F
+
O
−
HFP and FSO3 are generated by A/E of F− on FAFS as shown in Scheme 10.
Scheme 10. Addition/Elimination by F(−) on FAFS—Reaction products.
O
F-
+
FSO3
-
SF
CF3CF= CF2
O
CF2=CFC F2
+
O
Since F− anions are always present in the reaction medium due to the equilibrium shown in Scheme 8,
increasing the reaction temperature will effectively shift the equilibrium to the right, but it will at the
same time favor the side reactions just described. We therefore attempted the addition of an acyl
fluoride to FAFS at much lower temperatures. Table 9 shows the results obtained.
Table 9. Low-temperature (−20 °C~r.t) addition of different fluorinated acyl fluorides to
FAFS—Yields and selectivities.
Trial
27
28
29
30
RfCOF
COF2
CF3COF
CF3CF2COF
Perfluoroalkyl Allyl Ether Yield (Selectivity)
b.p. (°C)
11–12
39–40
48–49
105
CF3OCF2CF=CF2
CF3CF2OCF2CF=CF2
CF3CF2CF2OCF2CF=CF2
54(85)
86(96)
67(99)
84(94)
FSO2CF2COF FSO2CF2CF2OCF2CF=CF2
Depending on the acyl fluoride employed (see Experimental), the reaction temperatures varied from
−20 °C to r.t., in these conditions the acyl fluoride <==> alcoholate equilibrium is shifted to the left
but, unlike F− anions, the alcoholate slowly reacts with FAFS therefore obtaining good yields and
selectivities with minimal formation of byproducts. Table 10 shows the yields and selectivities
obtained by varying the solvent, reaction temperature and metal fluoride for the synthesis of
CF3OCF2CF=CF2.
Aprotic solvents favor the A/E reaction of F− anion on FAFS yielding HFP and FSO3 while the
−
absence of solvents favors the catalytic desulfurilation. The most favorable reaction conditions were
those of Trial 27e and they were applied to all of the other acyl fluorides reported in Table 9.

Molecules 2011, 16
6525
Table 10. Addition of COF2 to FAFS—Yields, selectivities and side-reaction products as a
function of reaction temperature and solvent (ACF = Acryloyl fluoride, CF2=CFC(=O)F).
Trial
27a
27b
27c
27d
27e
MF
CsF
CsF/NaF
CsF/NaF
KF
Solvent
Tetraglyme
-
TR
150 °C
RT
100 °C
−20 °C
−5 °C
Yield (%) (Selectivity %)
By-Products
HFP
SO2F2/ ACF
SO2F2/ ACF
HFP
10 (30)
/ (85)
/
9 (98)
54 (85)
-
Diglyme
Diglyme
KF
HFP
2.3.3. Halides
Table 11 shows the perfluoroallyl halides obtained by the A/E reaction with KI, KBr and KCl.
Based on the reaction temperature necessary for complete conversion of FAFS the following reactivity
scale was established: I− >> Br− > Cl−.
Table 11. Allyl halide yield as a function of the halide.
Nucleophile
TR (°C) tR (h)
FAFS Conversion
XCF2CF=CF2 Yield
KI
KBr
KCl
3 °C
20 °C
50 °C
2.5
2.5
2.5
100%
100%
98%
85%
56%
31%
All reactions were carried out for 2.5 h and the solvent system was 0.98 CH3CN/0.02 DMF (w/w).
Changing the solvent to diglyme, which is known to solubilize inorganic salts well, didn’t appreciably
change the conversion times or the yields obtained. We found that when CH3CN was employed, a very
low percentage of DMF was necessary to help solubilize the metal halide. All three perfluoroallyl
halides are synthons of FAFS and react in the same way FAFS does. ICF2CF=CF2, being the most
easily synthesized perfluoroallyl halide, was obtained in situ when it was absolutely necessary not
to have A/E vs. SN competition. Furthermore, unlike FAFS, ICF2CF=CF2 is hydrolytically stable at
least up to r.t. and can be employed in those nucleophilic reactions where an anhydrous solvent is
not available.
2.3.4. Azides
Reacting FAFS in an anhydrous CH3CN/NaN3 slurry at r.t. for 3 h the following main product
shown in Scheme 11 has been identified by 19F-NMR.
Scheme 11. Allyl azide synthesis.
FSO3Na
δ+
N
δ−
N
CF2CF=CF2
N
NaN3
CF2=CFCF2OSO2F
+
74%

Molecules 2011, 16
6526
2.3.5. H2O2
The nucleophilic A/E sum of H2O2 to FAFS was studied both in an aqueous biphasic system [21] as
well as in an anhydrous system. Scheme 12 shows the reactions involved in the peroxidation reaction.
Scheme 12. Diallylperoxide reaction mechanism.
HOO-
+
Na+
(a)
(b)
+
H2O
+ NaOH
HOOH
HOO-
-
+
+
CF2
OSO2F
CF2=CF
HOOCF2CF=CF2
FSO3
Na+
CF2=CFCF2OO-
OSO2F
(c)
(d)
H2O
+
+
HOOCF2CF=CF2
CF2=CFCF2OO-
+ NaOH
CF2=CF
-
+ FSO3
CF2=CFCF2OOCF2CF=CF2
+
CF2
3.3.5.1. Aqueous conditions
The reaction was carried out employing commercial aqueous 30% H2O2 (w/w; 0.5–5 equiv.) in the
presence of an inert fluorinated solvent (CFC 113, C6F14, CF3OCFClCF2Cl– “Methyl Adduct”–;
solvent/30% H2O2 = 4:1 by volume) and NaOH (1–2 equiv. vs. H2O2) between 0–20 °C for a total
reaction time of 10 min as already described elsewhere for similar reactions [21]. Table 12 shows the
results obtained.
Table 12. H2O2 addition to FAFS in aqueous conditions–Products and selectivities as a
function of Solvent/H2O ratio (v/v).
H2O2 Solvent/H2O TR
tR
FAFS
Trial
Products (Selectivity)
(eq.)
(v/v)
5/1
1/1
0
(°C) (min) Conversion
31
32
33
1
1
5
0
0
0–8
10
10
9
0%
10%
100%
-
CF2=CFCF2OOCF2CF=CF2 (89%)
CF2=CFCF2OOCF2CF=CF2 (26.7%)
(CF2=CFCO2)2 (11.8%)
(HOOCCFHCO2)2 (3.5%)
(CF3CFHCO2)2 (3.2%)
Other acids + peracids (54.9%)
Trials 31 and 32 show that one major problem of the reaction is the contact between FAFS and
H2O2 in the heterogeneous system, which doesn’t allow high conversions of FAFS. In trial 33 the
fluorinated solvent (CFC 113) was omitted in the attempt to create a better contact between the
reagents. At the end of the reaction phase separation was not clear cut suggesting the presence of
fluorinated acids and peracids which act as surfactants. Nonetheless, at 100% FAFS conversion, the
desired perfluoroallyl alkyl peroxide was obtained with 26.7% selectivity along with numerous other
peroxidic compounds shown in Table 13 where we also report the concentration of each peroxide as a
function of time, at 20 °C, as determined by quantitative 19F-NMR.

Molecules 2011, 16
6527
19
During the kinetic measurements shown in Table 13, F-NMR analyses indicated that the organic
−
material decomposed significantly to inorganic fluorides, (mainly MF and FSO3 ) and gaseous
byproducts identified as CF2=CFCF=CF2 (PFBD) and CO2. Table 14 shows the progress of the %
molar decomposition at 20 °C as function of time.
Table 13. Sum of aqueous H2O2 to FAFS—Products observed (19F-NMR) and their
decomposition as a function of time at 20 °C.
Compound
[c] (M) at
0.167 h
0.312
0
[c] (M) at 18 h [c] (M) at 24 h [c] (M) at 36 h
1: CF2=CFCF2OOCF2CF=CF2
2: CF2=CFCOF
0.0319
0
0.0289
0
0.0101
0
3: CF2=CFCOOH
0.264
0.1381
0.2516
0.04118
0.1264
0.0373
0
0.01135
0.000468
0.0445
0.000585
0.02094
0.000269
0.0819
0.09594
0.1041
0.01579
0
0.00316
0
4: CF2=CFC(=O)OOC(=O)CF=CF2
5: HOOCCFHCOOH
0.0498
0.000222
0.03194
0
0.02282
0
6: HOOCCFHC(=O)OOC(=O)CFHCOOH
7: CF3CFHCOOH
0.00878
0
8: CF3CFHC(=O)OOC(=O)CFHCF3
9: CF2=CFC(=O)OOH
0.02094
0
0.02691
0.06154
0.0875
10: CF3CFHC(=O)OOH
11: HOOCCFHC(=O)OOH
0
0
0.1802
The decomposition observed in Table 14 is to be attributed not only to the individual thermal kd of
the peroxides but also to the presence of H2O due to poor phase separation of the aqueous and organic
phases at the end of the reaction. It is known that hydrolytic decompositions, especially for fluorinated
diacyl peroxides, is several orders of magnitude faster than the thermal decomposition rate [21].
Table 14. Sum of aqueous H2O2 to FAFS—Decomposition of all of the organic products
as a function of time at 20 °C.
t = 10 min
0%
t = 18 h
62%
t = 24 h
65%
t = 36 h
76%
% decomposition
% residual organics
100%
33,2%
28,3
18,9%
Schemes 13 and 14 show the reactions involved that justify all of the peroxidic species identified in
Table 13. The thermal decomposition rate constants at 20 °C, kd and the respective half-lives of
peroxides 1, 4, 6 and 8 of Table 13 were calculated according to a first order radical decomposition
mechanism [21-24] defined by Equations 1 and 2:
(1)
ln[Peroxyde]t = −kdt + ln[Peroxyde]o
t
1/2 = ln2/kd
(2)

Molecules 2011, 16
6528
Scheme 13. Sum of aqueous H2O2 to FAFS—Reaction pathways that lead to the observed
reaction products.
HOO CCFHC(=O)O OH
H2O2
H2O
CF2=CFC(=O)OOH
HOOCCFHCOOH
H2O2/NaOH/H2O
H2O2
H2O
H2O
CF2=CFCO OH
CF3CFHC(=O)O OH
CF3CFHCOO H
H2O2
HF
H2O
H2O
H2O
2 /NaOH
CF2=CFCOF
CF2=CFCF2OSO 2F
CF2=CFCF2OOCF2CF=CF2
H2O2/H2O
H2O2
HOO CCFHCOF
CF2=CFC(=O)O OC(=O )CF=CF2
H2O2
HF
HOO CCFHC(=O)OO C(=O )CFHCO OH
CF3CFHC(=O)OOC(=O)CFHCF3
Scheme 14. Sum of aqueous H2O2 to FAFS—Thermal (20 °C) decomposition products of
dialkyl- and diacil peroxides.
.
O
C F 2
C F 2 = C F
O C F 2 C F = C F 2
2
C F = C F C F O
1
1 )
2
2
Δ
+
C F 2 = C F C F = C F 2
C O F
2
2
H O
2
2
C O
2
+
4
H F
2
O
.
C C F = C F
O
C F = C F C O
2 ) 1
C F 2 = C F
C
O
2
2
2
Δ
O
O
C O 2
+ 2
C F 2 = C F C F = C F 2

Molecules 2011, 16
6529
Figure 4 and Table 15 show respectively the decomposition kinetics and the linear regression
obtained from the data of Table 12 and used to determine both kd and t1/2 for peroxides 1, 4, 6 and 8.
Figure 4. Sum of aqueous H2O2 to FAFS—linear regression for the determination of the
thermal decomposition rate constant kd and half-life t1/2 at 20 °C for the peroxides observed.
18
6: HOOCCFHC(=O)-O-OC(=O)CFHCOOH 8: CF
3CFHC(=O)-O-O-C(=O)CFHCF
3
1: CF2=CFCF2-O-O-CF2CF=CF2
y = 0,3484x + 3,3187
y = 0,1927x + 3,496
R2 = 0,9758
y = 0,0951x + 1,3278
R2 = 0,9641
16
14
12
10
8
R2 = 0,9102
t
1/2 = 1,99 hrs
t
1/2 = 7,29 hrs
t
1/2 = 3,59 hrs
4: CF
2
=CFC(=O)O-O-C(=O)CF=CF
2
y = 0,325x + 2,3105
2 = 0,9341
R
t1/2 = 2,13 hrs
6
4
2
0
0
5
10
4
15
20
25
30
35
40
t (h)
Fit 4
1
6
8
Fit 1
Fit 6
Fit 8
Table 15. Sum of aqueous H2O2 to FAFS—kd and t1/2 at 20 °C for the peroxides observed.
Peroxide
1. CF2=CFCF2OOCF2CF=CF2
4. (CF2=CFCO2)2
kd × 108 (s−1)
2642
t1/2 (h)
7,29
2,13
9028
6. (HOOCCFHCO2)2
8. (CF3CFHCO2)2
5353
9678
3,59
1,99
We can observe in Table 15 that the perfluoroallyl peroxide 1 has a smaller kd and a longer t1/2
compared to the other peroxides. The kd of the fluorinated diacyl peroxides 4, 6 and 8 can’t be
compared with those of other diacyl peroxides found in the literature [21-23] since their structures and
MW are too different from those cited. It is in fact known that there is a good correlation between
diacyl peroxide structure and MW with the stability of the radical [22,24] coming from the homolytic
cleavage of the diacyl peroxide –O–O– bond. Instead, comparing the peroxides of Table 14 we can say
that the CF2=CFCF2O• radicals obtained from the homolytic cleavage of the –O–O– dialkyl peroxide 1
bond are less stable than the RfC(=O)O• radicals from homolytic cleavage of the –O–O– diacyl
peroxide bonds of peroxides 4, 6 and 8 (longer t1/2 and a smaller kd).
The correlation of the molar concentrations of the carboxylic acids 3, 7, and 5 and the respective
19
peracids 9, 10 and 11 as a function of time is reported in Figure 5 (data from quantitative F-NMR).
The curves in Figure 5 were obtained by fitting the experimental concentrations reported in Table 13 to
a 3rd degree polynomial equation. The acid-peracid couples (acids: Dotted curves; peracids: Whole
curves) are essentially complementary: As the concentration of a peracid increases, the corresponding
acid concentration decreases.

Molecules 2011, 16
Figure 5. Sum of aqueous H2O2 to FAFS—Acid-peracid equilibria.
6530
0,3
0,25
0,2
9: CF
2
=CFC(=O)-O-OH
3: CF
7: CF
2
=CFCOOH
CFHCOOH
10: CF
3CFHC(=O)-O-OH
3
9
11: HOOCCFHC(=O)-O-OH
5: HOOCCFHCOOH
10
11
3
0,15
0,1
7
5
Fit 9
Fit 10
Fit 11
Fit 3
Fit 7
Fit 5
0,05
0
0
5
10
15
20
25
30
35
40
-0,05
-0,1
t (h)
2.3.5.2. Anhydrous conditions
The presence of water in the FAFS peroxidation gives several compounds having a peroxidic bond.
In order to increase the desired perfluorodiallyl peroxide 1 selectivity and decrease the total number
of acids and peracids, we tested three different anhydrous or nearly anhydrous reactions with H2O2
and FAFS:
• Method A
Na2O2 + H2SO4(96%) ---------> H2O2(96% +H2O 4%) + Na2SO4 ---------> (CF2=CFCF2O)2
THF; 0 °C FAFS; CFC 113.
• Method B
Na2O2 + 2 H2O2(30%) ------> H2O2(30%) + 2 NaOH +O2 ------> (CF2=CFCF2O)2
CH2Cl2; 0 °C FAFS.
• Method C
H2O2(30%) + CaH2 ------> H2O2(100%) + Ca(OH)2 + 2H2 -------> (CF2=CFCF2O)2
CH3CN; N2; −15 °C FAFS; CH3CN.
The results are summarized in Table 16. Method A which involved nearly anhydrous and acidic
conditions gave no reaction and FAFS was recovered completely. Method B had approximately the
same molar content of H2O as Method A, but with a basic pH. In this case FAFS converts completely
and yields five products (as compared to 11 different products in the aqueous reaction conditions): The
desired perfluorodiallyl peroxide has a selectivity = 32%. Method C is completely anhydrous and
yields almost exclusively perfluorodiallyl peroxide 1. The drawback of this method, is that it generates

Molecules 2011, 16
6531
100% H2O2, which is potentially explosive. The data presented in this section suggest that the
selectivity of CF2=CFCF2–O–O–CF2CF=CF2 depends greatly on the anhydrousness of the reaction.
Table 16. Addition of anhydrous H2O2 to FAFS—Product distributions and selectivities.
Trial
34
35
Method FAFS Conversion (%mol)
Products (Selectivity %)
No Reaction
CF2=CFCF2O-O-CF2CF=CF2 (32%)
(CF3CFHCO2)2 (2,2%)
A
B
0%
100%
HOOCCFHCOOH (17,3%)
(HOOCCFHCO2)2 (42,8%)
CF3CFHCOOH (5,8%)
36
C
90%
CF2=CFCF2O-O-CF2CF=CF2
2.3.6. Ketones
Scheme 15 shows the synthesis of a branched allyl ether that can be obtained by reacting a ketone,
in this specific case perfluoro isopropyl trifluorometyl ketone, with a metal fluoride followed by
addition of FAFS to the alcoholate in much the same manner as was done with the addition of
perfluorinated acyl fluorides to FAFS in section (ii). The perfluroketone is easily prepared by reacting
a perfluorinated olefin, in this case HFP, with a stoichiometric amount of a fluorinated acyl fluoride, in
this case acetyl fluoride, in the presence of a catalytic amount of a metal fluoride.
As with the previously discussed acyl fluorides, the alcoholate is formed in the presence of an
aprotic solvent, such as anhydrous diglyme which solvates well the oxyanion thereby shifting the
equilibrium reaction to the right much like Trial 27e in Table 10, at reaction temperature ranging
between 0–5 °C. The only major difference encountered in the reaction of the branched fluorinated
alcoholate of Scheme 15 and the linear fluorinated alcoholates of Table 9 is the reaction time:
branched alcoholates reacted with FAFS much more slowly (10–12 h) than linear alcoholates (3–4 h).
This can probably be attributed to steric reasons due to the greater difficulty of the branched oxyanion
to approach FAFS’ terminal double bond as opposed to the less hindered fluorinated oxyanions. The
yield of the branched allyl ether is also lower, 49% vs. 54%–86% for the linear perfluorinated
oxyanions.
Scheme 15. Reaction mechanism for the addition of a ketone to FAFS.
3. Experimental
3.1. General
19F-NMR spectra were recorded on a Varian Mercury 200 MHz spectrometer using CFCl3 as
internal standard. The error on the measurement of the integrated intensities was ±5%. FT-IR spectra

Molecules 2011, 16
6532
were recorded on a Nicolet Avatar 360 FT-IR ESP interfaced with OMINC software. Gas
chromatographic analyses were performed on a Carlo Erba GC 8000 Top gas chromatographer using a
silicone wide bore 0.54-micron thick 25 meters long column. Unless otherwise stated, all commercial
reagents were used without further purification. All reported NMR chemical shifts are expressed in ppm.
Caution! Due to the high toxicity of SO3, BF3 and several monomers described hereforth, in
particular ICF2CF=CF2, all reactions must be carried out in an efficient fume-hood wearing appropriate
lab apparel.
3.2. Synthesis of CF2=CFCF2OSO2F (FAFS)
The following is a modified and revised procedure of FAFS [1-5]. Freshly distilled SO3 (50 g,
0.625 mol; b.p. = 43 °C) from 65% (w/w) oleum (Merck Industries) were placed in a glass Carius tube
and connected to a BF3 bomb; 0.85 g of BF3 (1.7% w/w) were bubbled in the SO3 and dissolved with
vigorous shaking. After 3 h a homogeneous, transparent and tanned colored solution is obtained. Care
must be taken not to let T < 15 °C otherwise the irreversible SO3 polymerization will occur even in the
presence of the BF3/SO3 complex (Schemes 1 and 16). The SO3 solution is transferred in a stainless
steel 0.5 L autoclave, which is under vacuum. The autoclave is placed on a rocker at 25 °C and HFP
(1.13 mol = 168.8 g) are pumped in the autoclave in 15–20 min. The temperature is raised to 37 °C for
12 h with constant rocking. The autoclave is then cooled to 0 °C, the excess HFP is evacuated and the
crude, fuming reaction mixture is fractionally distilled.
Scheme 16. SO3-Boron complex in FAFS synthesis.
F-
CF2=CFCF2OSO2F
B
CF3CF=CF2
+
OSO2F
19
CF2=CFCF2OSO2F is obtained in 67 mol % yield vs. SO3 (96 g; b.p. = 64 °C); F-NMR (CFCl3,
std): +50 (s; 1F; –OSO2F); −71 (s; 2F; –CF2O–); −88; 2JFF = 82, 3JFF = 64 (dd; 1F; cis CF2=); −102.0;
3
2JFF = 85, JFF = 112 (ddt; 1F; trans CF2=); −190.5 (m; 1F; CF2=CF–); FT-IR (KBr): 1790 cm−1
(CF2=CFCF2–; st.); 1278 cm−1; 1166 cm−1; 1034 cm−1 (–CF–; st).
3.3. Synthesis of CF2=CFCF2OCH3—Without Basic Catalysis
CH3OH (15 g, 0.47 mol) are cooled to 0 °C with stirring; FAFS (8 g, 0.035 mol) are slowly added
with a dropping funnel taking care not to exceed 15 °C. The reaction mixture is warmed to 20 °C and
allowed to stir for 1 h. The crude mixture is washed twice with 30 mL H2O and dried over MgSO4.
CF2=CFCF2OCH3 is obtained in 67 mol % yield (3.8 g) vs. FAFS. 19F-NMR (CFCl3, std): −73.5
2
3
2
3
(m; 2F; –CF2–O); −92.0; JFF = 83, JFF = 65 (dd; 1F; cis CF2=); −102.0; JFF = 85, JFF = 111 (ddt;
1
1F; trans CF2=); −189.0 (m; 1F; –CF2=CF–); H-NMR (TMS, std): 3.35 (s; 3H; CH3O–); FT-IR
(KBr): 1785 cm−1 (CF2=CFCF2–; st); 1275 cm−1; 1157 cm−1; 1040 cm−1 (–CF–; st).

Molecules 2011, 16
6533
3.3.1. Synthesis of CF2=CFCF2OCH2CF3—without basic catalysis
CF3CH2OH (13 g, 0.13 mol) was cooled to 0 °C with stirring; FAFS (6 g, 0.026 mol) was slowly
added with a dropping funnel taking care not to exceed 15 °C. The reaction mixture is warmed to
20 °C and allowed to stir for 1 h. The crude mixture is washed twice with H2O (30 mL) and dried over
MgSO4. CF2=CFCF2OCH2CH3 is obtained in 46 mol % yield (2.1 g) vs. FAFS.
3.3.2. Synthesis of CF2=CFCF2OCH2CF3—with basic catalysis
CF3CH2OH (14 g, 0.14 mol) are added to KOH (1 g, 0.0178 mol) and mixed at 20 °C until a
homogeneous solution is obtained. The mixture is cooled to 0 °C and FAFS (6 g, 0.026 mol) is slowly
added with a dropping funnel making sure not to exceed an internal temperature of 15 °C. The reaction
mixture is warmed to 20 °C and let stir for 2 h. The crude mixture is the washed with H2O and the
organic phase is dried over MgSO4. CF2=CFCF2OCH2CF3 is obtained in 75% yield (4.5 g) vs. FAFS.
19F-NMR (CFCl3, std): −73.2 (t; 3F; J = 13.2 Hz, 6.6 Hz; CF3–CH2–); −73.0 (m; 2F; –CF2–O); −92.5;
3
2
3
2JFF = 82, JFF = 63 (dd; 1F; cis CF2=); −104.5; JFF = 83, JFF = 112 (ddt; 1F; trans CF2=); −189.5
(m; 1F; –CF2=CF–); H-NMR (TMS, std): 4.4 (q; 2H; CF3CH2O–); FT-IR (KBr): 1790 cm−1
(CF2=CFCF2–; st); 1275 cm−1; 1166 cm−1; 1040 cm−1 (–CF–; st).
1
3.4. Synthesis of CF2=CFCF2OC6F5, CF2=CFCF2OC6H5 and CF2=CFCF2OCH2C6H5
The following detailed procedure is for CF2=CFCF2OC6F5. The same procedure and molar
quantities were employed for CF2=CFCF2OC6H5 and CF2=CFCF2OCH2C6H5. A heterogeneous
mixture of NaH (2.76 g, 115 mmol) and anhydrous THF (20 mL) was cooled to 15 °C and stirred for
30 min. The mixture is cooled further to 4 °C and C6F5OH (20.1 g, 109 mmol) diluted in anhydrous
THF (50 mL) are dripped in at a rate of 10 mmol/min. The reaction is exothermic (+20 °C) and its
completion (10 min) is monitored by observing the 19F-NMR shift of the para F from –171 ppm
(C6F5OH) to –187 ppm (C6F5O−Na+). FAFS (25 g, 109 mmol) is slowly added making sure not to
exceed an internal temperature of 30 °C. After 60 min the reaction is complete and FAFS
19
conversion = 100% as evidenced by F-NMR. The crude mixture is first filtered separating FSO3Na
(13.5 g) and then distilled. CF2=CFCF2OC6F5 is obtained in 56% isolated yield (18.2 g, 61 mmol), b.p.
= 57 °C at 14 mm Hg = 160 °C at 760 mm Hg. CF2=CFCF2OC6H5 is obtained in 87% isolated yield
(21.2 g, 94.8 mmol). CF2=CFCF2OCH2C6H5 is obtained in 50% isolated yield (12.9 g; 54.5 mmol).
2
3
CF2=CFCF2OC6F5: 19F-NMR (CFCl3, std): −70.2 (m; 2F; –CF2–O); −88.5; JFF = 83, JFF = 64
(dd; 1F; cis CF2=); −102.0; 2JFF = 85, 3JFF = 110 (ddt; 1F; trans CF2=); −150.7 (m; 2F; ortho–);−154.6
(t; 1F; para–); −160.6 ppm (t; 2F; meta–); −188.9 ppm (m; 1F; CF2=CF–); FT-IR (KBr): 1785 cm−1
(CF2=CFCF2–; st); 1625 cm−1; 1525 cm−1 (–C=C–; st; Ar); 1250 cm−1; 1155 cm−1; 1015 cm−1 (–CF–; st).
19
2
3
CF2=CFCF2OC6H5: F-NMR (CFCl3, std): −70.1 (m; 2F; –CF2–O); −90.5; JFF = 83, JFF = 64 (dd;
2
3
1F; cis CF2=); −103.5; JFF = 85, JFF = 110 (ddt; 1F; trans CF2=); −187.4 (m; 1F; CF2=CF–); FT-IR
(KBr): 1789 cm−1 (CF2=CFCF2–; st); 1535 cm−1 (–C=C–; st; Ar), 1270 cm−1; 1150 cm−1; 1035 cm−1
(–CF–; st); 1H-NMR (TMS, std): 7.35, 7.2, 7.1 (m; 2H:1H:2H; –OC6H5).

Molecules 2011, 16
CF2=CFCF2OCH2C6H5: F-NMR (CFCl3, std): −70.0 (m; 2F; –CF2–O); −92.5; JFF = 81, JFF = 63
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19
2
3
2
3
(dd; 1F; cis CF2=); −104.5; JFF = 83, JFF = 111 (ddt; 1F; trans CF2=); −187.0 (m; 1F; CF2=CF–);
FT-IR (KBr): 2985 cm−1 (–CH2O–Ar; st); 1789 cm−1 (CF2=CFCF2–; st.); 1590 cm−1; 1480 cm−1
(–C=C–; st; Ar); 1270 cm−1; 1150 cm−1; 1035 cm−1 (–CF–; st); 1H-NMR (TMS, std): 7.15, 7.1, 7.0 (m;
2H:1H:2H; –OCH2C6H5); 4.4 (–OCH2–Ar).
3.5. Synthesis of 2,4-Dinitrophenyl Perfluoroallyl Ether; CF2=CFCF2OC6H3(NO2)2 and p-Nitro
Phenyl Perfluoroallylether CF2=CFCF2OC6H4(NO2)
The following detailed procedure is for CF2=CFCF2OC6H3(NO2)2. The same procedure and molar
quantities were adopted for CF2=CFCF2OC6H4(NO2). A heterogeneous mixture of NaH (1.5 g, 63 mmol)
and anhydrous CH3CN (20 mL) was cooled to 15 °C and stirred for 30 min. The mixture is cooled
further to 5 °C and C6H3(NO2)2OH, (10 g, 53 mmol) dissolved in anhydrous CH3CN (95 mL) was
dripped in at a rate of 10 mmol/min. The reaction is exothermic and care was taken to not exceed an
internal temperature of 10 °C. At the end of the exotherm, phenate formation was complete and FAFS
(12.5 g, 54 mmol) were added at a rate of 20 mmol/min. The reaction is modestly (+2 °C) exothermic.
After 3 h the reaction was stopped. FAFS conversion = 81% (pushing the conversion lowered
selectivity from 85% to 78%). The crude mixture was first filtered to remove FSO3Na, then washed
with aqueous Na2CO3 (pH = 10, 200 mL) and finally flash chromatographed on silica gel eluting with
CH2Cl2. CF2=CFCF2OC6H3(NO2)2 is obtained in 55% yield (9.3 g, 29.7 mmol). CF2=CFCF2OC6H4(NO2)
is obtained in 75% isolated yield (10.9 g, 40.5 mmol).
CF2=CFCF2OC6H3(NO2)2: 19F-NMR (CFCl3, std): −70.0 (m; 2F; –OCF2CF=); −91.0; 2JFF = 81, 3JFF = 65
2
3
(dd; 1F; cis CF2=); −103.7; JFF = 82, JFF = 113 (ddt; 1F; trans CF2=); −191 (m; 1F; CF2=CF–);
1H-NMR (TMS, std): 8.55 (m; 1H; –C(NO2)=CHC(NO2)–); 8.32 (m; 1H; –OC=CH–CH=C(NO2)–); 7.6
(m; 1H; OC=CH–CH=C(NO2)–); FT-IR (KBr): 1520 cm−1 (symm.; Ar–NO2; st); 1345 cm−1 (asymm.;
Ar–NO2; st); 1789 cm−1 (CF2=CFCF2–; st); 1600 cm−1; 1450 cm−1 (–C=C–; st; Ar); 1270 cm−1; 1150 cm−1;
1035 cm−1 (–CF–; st).
CF2=CFCF2OC6H4(NO2): 19F-NMR (CFCl3, std): −70.1 (m; 2F; –OCF2CF=); −91.2; 2JFF = 83, 3JFF = 64
2
3
(dd; 1F; cis CF2=); −102.5; JFF = 85, JFF = 110 (ddt; 1F; trans CF2=); −189.4 (m; 1F; CF2=CF–);
1H-NMR (TMS, std): 8.47 (m; 2H; =CH–C(NO2)=CH–); 7.6 (m; 2H; =CH–C(ORf)=CH–); FT-IR
(KBr): 1525 cm−1 (symm.; Ar–NO2; st); 1335 cm−1 (asymm.; Ar–NO2; st); 1789 cm−1 (CF2=CFCF2–;
st); 1620 cm−1; 1440 cm−1 (–C=C–; st; Ar); 1270 cm−1; 1150 cm−1; 1035 cm−1 (–CF–; st).
3.6. Synthesis of m-Cresol Perfluoroallylether CF2=CFCF2OC6H4–CH3
A heterogeneous mixture of NaH (1.5 g, 63 mmol) and anhydrous CH3CN (20 mL) was cooled to
15 °C and stirred for 30 min. The mixture is cooled further to 5 °C and a solution of m-C6H4CH3OH,
(6.48 g, 60 mmol) in anhydrous CH3CN (75 mL) was dripped in at a rate of 10 mmol/min. The
reaction is exothermic and care was taken to not exceed an internal temperature of 10 °C. At the end of
the exotherm, phenate formation was complete and FAFS (13.8 g, 60 mmol) were added at a rate of
20 mmol/min. The reaction is modestly (+2 °C) exothermic. After 3 h the reaction was stopped. The

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crude mixture was first filtered to remove FSO3Na, then washed with aqueous Na2CO3 (pH = 10,
200 mL) and finally flash chromatographed on silica gel eluting with CH2Cl2. CF2=CFCF2OC6H4CH3
is obtained in 48% yield (5.9 g; 24.8 mmol). 19F-NMR (CFCl3, std): −61 (s; 3F; Ar–CF3); −68.7 (m; 2F;
2
3
2
3
–OCF2CF=); −91.3; JFF = 82, JFF = 63 (dd; 1F; cis CF2=); −103.7; JFF = 83, JFF = 110 (ddt; 1F;
trans CF2=); −188.5 (m; 1F; CF2=CF–); FT-IR (KBr): 2995 cm−1 (CH3–Ar; st); 1792 cm−1
(CF2=CFCF2–; st); 1580 cm−1; 1380 (–C=C–; st; Ar); 1275 cm−1; 1156 cm−1; 1030 cm−1 (–CF–; st).
3.7. Synthesis of CF3OCF2CF=CF2
Anhydrous KF (1.7 g; 30.3 mmol; 800 ppm residual H2O) was placed in a stainless steel autoclave.
The autoclave is evacuated and cooled to –100 °C. Anhydrous diglyme (20 mL; 55 ppm residual H2O)
and COF2 (2.3 g; 35 mmol) are condensed in the autoclave which is then warmed to 5 °C. The mixture
is magnetically stirred at 1,000 rpm for 2 h in order to form the alcoholate. FAFS (6.7 g; 29 mmol) was
then added from a pressurized (He; 7 atm) cylinder. The reaction is kept stirring at 5 °C for 1 h and 4 h
at 20 °C. The crude mixture is then distilled directly from the autoclave under reduced pressure. The
fraction boiling at 11 °C was identified as CF3OCF2CF=CF2 (3.38 g, 15.7 mmol). Isolated yield = 54%
19
2
vs. FAFS. F-NMR (CFCl3, std): −53.5 (s; 3F; CF3O–); −71.7 (m; 2F; –OCF2CF=); −87.8; JFF = 82,
3JFF = 65 (dd; 1F; cis CF2=); −101.3; JFF = 83, JFF = 111 (ddt; 1F; trans CF2=); −190.3 (m; 1F;
CF2=CF–); FT-IR (KBr): 1787 cm−1 (CF2=CFCF2–; st); 1270 cm−1; 1156 cm−1; 1025 cm−1 (–CF–; st).
2
3
3.8. Synthesis of CF3CF2OCF2CF=CF2
Anhydrous KF (36.5 g; 630 mmol) are placed in a glass round bottomed flask equipped with a
condenser (−78 °C), a magnetic stir bar, a dropping funnel and a thermometer. Anhydrous diglyme
(400 mL) is added along with CF3COF (78 g; 670 mmol; b.p. = −56 °C) previously condensed in an
Erlenmeyer flask. The reaction flask is warmed to 5 °C and stirred for 1 h. FAFS (150 g; 630 mmol) is
then slowly added taking care not to exceed 10 °C inside the flask. The reaction is let stir at 5 °C for 1 h
and then 4.5 h at 20 °C. Already after 1 h at 20 °C the crude mixture separates into two phases. The
product is distilled and 142 g of the fraction boiling at 39–40 °C were collected and identified as
19
CF3CF2OCF2CF=CF2. Yield = 86%. F-NMR (CFCl3, std): −86 (m; 2F; CF3CF2–O–); −84.3 (s; 3F;
2
3
2
CF3–); −69.5 (m; 2F; –OCF2CF=); −87.5; JFF = 83, JFF = 64 (dd; 1F; cis CF2=); −101; JFF = 85,
3JFF = 110 (ddt; 1F; trans CF2=); −189.3 (m; 1F; CF2=CF–); FT-IR (KBr): 1792 cm−1 (CF2=CFCF2–; st);
1273 cm−1; 1186 cm−1; 1027 cm−1 (–CF–; st).
3.9. Synthesis of CF3CF2CF2OCF2CF=CF2
Anhydrous KF (1.4 g; 24 mmol) was placed in a glass round bottomed flask equipped with a
condenser (−78 °C), a magnetic stir bar, a dropping funnel and a thermometer. Anhydrous diglyme
(18 mL) was added along with CF3CF2COF (4.1 g; 24 mmol), previously condensed in a Carius tube.
The reaction flask is warmed to 5 °C and stirred for 1 h. FAFS (6 g; 26 mmol) are then slowly
added taking care not to exceed 10 °C inside the flask. The reaction is allowed to stir at 5 °C for 1 h
and then 3 h at 20 °C. Already after 1 h at 20 °C the crude mixture separates into two phases. The
product is distilled and 6 g of the fraction boiling at 47–49 °C were collected and identified as

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19
CF3CF2CF2OCF2CF=CF2. Yield = 84%. F-NMR (CFCl3, std): −71.5 (m; 2F; =CFCF2–O); −81.5 (s;
3F; CF3–); −84.7 (s; 2F; CF3CF2CF2O–); −89.7; 2JFF = 81, 3JFF = 65 (dd; 1F; cis CF2=); −103.1; 2JFF = 83,
3JFF = 112 (ddt; 1F; trans CF2=); −130.2 (s; 2F; CF3CF2CF2O–); −192.5 (m; 1F; CF2=CF–); FT-IR
(KBr): 1788 cm−1 (CF2=CFCF2–; st); 1270 cm−1; 1150 cm−1; 1145 cm−1; 1035 cm−1 (–CF–; st).
3.10. Synthesis of FSO2CF2CF2OCF2CF=CF2
Anhydrous KF (1.1 g; 19.6 mmol) and anhydrous diglyme (3 mL) were placed in a glass round
bottom flask equipped with a condenser (−10 °C), a magnetic stir bar, a dropping funnel and a
thermometer. FSO2CF2COF (3.3 g; 18.3 mmol; b.p. = 28 °C) was added directly from the stainless
steel cylinder with a PTFE steel-glass connector. The mixture is stirred at 0 °C for 45 min and then
FAFS (4.3 g; 18.7mmol) was slowly added taking care not to exceed an internal temperature of 10 °C.
The mixture is stirred at 1,000 rpm for 3 h during which time FSO3K is formed. The crude mixture is
distilled and the fraction boiling at 105 °C was identified as FSO2CF2CF2OCF2CF=CF2 (5.1 g).
Yield = 84%. 19F-NMR (CFCl3, std): +46 (s; 1F; –SO2F); −111 (s; 2F; FSO2CF2–); −81 (s; 2F;
2
3
2
3
FSO2CF2CF2O–); −90; JFF = 83, JFF = 64 (dd; 1F; cis CF2=); −103; JFF = 85, JFF = 110 (ddt; 1F;
trans CF2=); −70 (s; 2F; –OCF2CF=); −190 (m; 1F; CF2=CF–); FT-IR (KBr): 1792 cm−1
(CF2=CFCF2–; st); 1275 cm−1; 1160 cm−1; 1041 cm−1 (–CF–; st).
3.11. Synthesis of CF2=CFCF2O-OCF2CF=CF2
3.11.1. Aqueous H2O2 route (Trial 33; Table 11)
NaOH (0.19 g, 4.8 mmol) was dissolved in H2O (2 mL) and placed in a glass round bottom flask
equipped with a “Micro-mix” mechanical stirrer, a dropping funnel, a condenser (−78 °C) and a
thermometer. Care is taken to treat all glassware with dichromate solution prior to performing the
reaction in order to eliminate all possible organic residues that may decompose the peroxides. The
mixture is cooled to 0 °C and stirred at 750 rpm. Aqueous H2O2 (30% w/w; 240 μL, 2.39 mmol 100%
H2O2) is added with a micro-syringe and the mixture is stirred at 0 °C for 5 min. FAFS (1.0 g,
4.35 mmol) are dripped in every 5–10 seconds. There is an immediate temperature increase; the
maximum internal temperature was 8 °C (TMAX), which was reached in 6 min. After TMAX, the internal
temperature dropped to 2 °C in 3 min. The peroxidation reaction is over in a total reaction time of
9 min. The crude mixture is immediately separated in a pre-chilled separation funnel collecting
the lower, organic phase (not a clear-cut separation), which was placed in an NMR tube thermostated
at 20 °C for kinetic measurements. FAFS conversion = 100%; CF2=CFCF2O–OCF2CF=CF2
yield = selectivity = 26.7%.
3.11.2. Anhydrous H2O2 route
CaH2 (0.44 g, 10.56 mmol) dispersed in CH3CN (3 mL) was placed in a glass round bottom flask
equipped with a “Micro-mix” mechanical stirrer, a dropping funnel, a condenser (−78 °C) and a
thermometer. Care is taken to treat all glassware with dichromate solution prior to performing the
reaction in order to eliminate all possible organic residues that may decompose the peroxides. The
dispersion is stirred at 750 rpm at 20 °C for 30 min. The apparatus is then fluxed with N2 (5 L/h) and

Molecules 2011, 16
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then H2O2 (30% w/w; 0.271 g, 2.39 mmol H2O2 100%; 10.56 mmol H2O) is added quickly. No
exothermicity was observed. FAFS (1.0 g; 4.35 mmol), previously diluted in anhydrous CH3CN
(0.5 mL) is quickly added. The reaction is exothermic and reached TMAX = 27 °C in 5 min. In order to
contain the reaction exothermicity, the reaction was periodically dipped in an ethanol/dry ice bath at
–15 °C. The reaction temperature returned to 0 °C in 10 min and was kept stirring at 0 °C for 30 min.
The reaction was then warmed to 20 °C and stirred for an additional 2 h. The crude reaction mixture
was filtered to separate Ca(OH)2 obtaining a colorless, clear solution. CF2=CFCF2O–O–CF2CF=CF2
yield = 32%.
19F-NMR (CFCl3, std):
CF2=CFCF2O–OCF2CF=CF2: −81.4 (m; 4F; –O–OCF2–); −89.5 (m; 2F; –CF2=CF–); −104.3 (m;
2F; –CF2=CF–); −188.8 (m; 2F; –CF2=CF–).
CF2=CFC(=O)O–OC(=O)CF=CF2: −80.6 (dd; 2F; –CF2=CF–); −92.6 (ddt; 2F; –CF2=CF–);
−186.4 (m; 2F; –CF2=CF–).
HOOCCFHCOOH: −192.2 (d; 1F; –CFH–; JF,H = 56 Hz).
HOOCCFHC(=O)O–OC(=O)CFHCOOH: −195.2 (d; 2F; –CFH; JF,H = 56 Hz).
CF3CFHCOOH: −86.6 (m; 3F; CF3–); −200.8 (dm; 1F; –CFH; JF,H = 56 Hz).
CF3CFHC(=O)O–O–C(=O)CFHCF3: −86.9 (m; 6F; CF3–); −204.6 (dm; 2F;–CFH–; JF,H = 56 Hz).
CF2=CFC(=O)–O–OH: −82.3 (dd; 1F; CF2=CF–); −93.1 (dd; 1F; CF2=CF–); −182.4 (dd; 1F;
CF2=CF–).
CF3CFHC(=O)–O–OH: −86.3 (m; 3F; CF3–); −200.6 (dm; 1F; –CFH–; JF,H = 55 Hz).
HOOCCFHC(=O)O–OH: −191.7 (d; 1F; –CFH–; JF,H = 50 Hz).
CF2=CFCOOH: −82.9 (dd; 1F; CF2=CF–); −93.5 (dd; 1F; CF2=CF–); −182.2 (dd; 1F; CF2=CF–).
3.12. Synthesis of (CF3)2CFCF(CF3)O–CF2CF=CF2
3.12.1. Synthesis of (CF3)2CFC(=O)CF3
Anhydrous KF (2.0 g, 34 mmol) and anhydrous diglyme (20 mL) are placed in a stainless steel
autoclave equipped with a magnetic stir bar and a pressure transducer. The autoclave is first evacuated
and cooled to –100 °C and then CF3C(=O)F (20 g, 172 mmol) and HFP (25.8 g, 172 mmol) are
condensed in the autoclave. The autoclave is heated to 100–110 °C and stirred at 1,000 rpm for 8 h.
The autoclave is cooled to 20 °C and the residual pressure of unreacted reagents is slowly bleeded
away. The crude diglyme mixture is first filtered to remove KF and then distilled. The fraction boiling
19
at 30–35 °C was identified as (CF3)2CFC(=O)CF3. Isolated yield = 70% (32 g; 120 mmol). F-NMR
(CFCl3, std): −74.4 (m; 6F; (CF3)2CF–); −76.1 (m; 3F; CF3C(=O)–); −192.5 (h; 1F (CF3)2CF–).
3.12.2. Synthesis of (CF3)2CFCF(CF3)O–CF2CF=CF2
Anhydrous KF (2.18 g, 37.5 mmol) was suspended in anhydrous diglyme (15 mL) and stirred at
1,000 rpm for 15 min at 0 °C. (CF3)2CFC(=O)CF3 (10 g, 37.6 mmol) was added within 10 min and
alloed to stir for 3 h. FAFS (9.2 g, 40 mmol) was added in 15 min and the reaction mixture is stirred at
0 °C for 4 h and then warmed to 10 °C and stirred for an additional 8 h. The crude mixture was filtered
to remove FSO3K and then washed twice with distilled H2O. Yield = 49% (7.7 g). 19F-NMR (CFCl3, std):

Molecules 2011, 16
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−67.6 (m; 2F; =CFCF2–O); −70.0 (dm; 6F; (CF3)CF–) (m; 3F; –OCF(CF3)–); −92 (m; 1F; JF,F = 48 Hz;
CF2=); −104.4 (m; 1F; JF,F = 117 Hz, 27 Hz; CF2=); −133.2 (q; 1F; JF,F = 17 Hz, –OCF(CF3)–CF–);
−182.0 (h; 1F; (CF3)2CF–); −189 (dm; 1F; JF,F = 40 Hz, 118 Hz; CF2=CF–CF2–); FT-IR (KBr): 1791.5
cm−1 (CF2=CFCF2–; st); 1250 cm−1; 1222 cm−1; 1084 cm−1; 1013 cm−1 (–CF–; st).
3.13. Synthesis of CF2=CFCF2N3
NaN3 (2.82 g, 43.4 mmol) was suspended in anhydrous CH3CN (10 mL) and stirred at 20 °C for
15 min. FAFS (10 g, 43.5 mmol) is added in 5 min and the mixture was stirred at 20 °C for 3 h. The
mixture was filtered and analyzed. FAFS conversion = 98%; CF2=CFCF2N3: selectivity = 74%.
19
Non-isolated yield 72%. CAUTION! The allyl azide could be explosive [25]. F-NMR (CFCl3, std):
2
3
2
−76.0 (m; 2F; –NCF2CF=); −92.5; JFF = 82, JFF = 63 (dd; 1F; cis CF2=); −105.0; JFF = 85,
3JFF = 112 (ddt; 1F; trans CF2=); −190.0 (m; 1F; CF2=CFCF2O–).
3.14. Synthesis of ICF2CF=CF2
Anhydrous KI (1.52 g, 9.13 mmol) was suspended in CH3CN (5.0 mL) and anhydrous DMF
(0.1 mL) in a glass round bottom flask equipped with a dripping funnel, a magnetic stir bar, a condenser
(10 °C) and a thermometer. The heterogeneous mixture is cooled to 0 °C with stirring (750 rpm). FAFS
(2.0 g, 8.69 mmol) was added in 3 min. The maximum exothermicity observed was +4 °C after
10 min. After 3 h at 0 °C FAFS conversion = 100%. The crude mixture is filtered and distilled. The
fraction boiling at 41 °C was identified as ICF2CF=CF2 (1.85 g, 7.1 mmol). Yield = 82%.
BrCF2CF=CF2 and ClCF2CF=CF2 were synthesized in an analogous manner.
2
3
ICF2CF=CF2: 19F-NMR (CFCl3, std): −48 (t; 2F; –CF2I); −92; JFF = 83, JFF = 65 (dd; 1F; cis
CF2=); −102.0; 2JFF = 85, 3JFF = 110 (ddt; 1F; trans CF2=); −175 (m; 1F; CF2=CF–).
BrCF2CF=CF2: 19F-NMR (CFCl3, std): −58.2 (t; 2F; –CF2Br); −96; 2JFF = 84, 3JFF = 66 (dd; 1F; cis
CF2=); −106.3; 2JFF = 85, 3JFF = 111 (ddt; 1F; trans CF2=); −186 (m; 1F; CF2=CF–).
19
2
3
ClCF2CF=CF2: F-NMR (CFCl3, std): −77 (t; 2F; –CF2Cl); −93, JFF = 84, JFF = 67 (dd; 1F; cis
CF2=); −104.5; 2JFF = 83, 3JFF = 112 (ddt; 1F; trans CF2=); (m; 1F; CF2=); −186.5 (m; 1F; CF2=CF–).
4. Conclusions
FAFS was demonstrated to be an easily synthesizable, extremely versatile and useful monomer for
preparing a wide selection of perfluoroallyl monomers such as fluorinated or partially fluorinated
aromatic and aliphatic allyl ethers, allyl halides, diallyl-alkyl peroxides and allyl azides respectively
from readily available alcohols, phenols, acyl fluorides, ketones, metal halides, H2O2 and sodium azide.
According to the conditions employed, FAFS can be directed to perform Addition/Elimination
reactions versus Substitution reactions yielding respectively perfluoroallyl ethers and perfluoroallyl
sulfate esters. These novel allylic compounds have the potential of becoming useful co-monomers or
modifying agents for fluoropolymers.

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Acknowledgments
The authors wish to thank Silvia Grossi for the high degree of professionality demonstrated in the
synthesis of the aliphatic, aromatic and halide allyl ethers, Roberto Biancardi and Stefano Radice for
helpful discussions in the interpretation of the 19F-NMR and FT-IR spectra respectively.
Conflict of Interest
The authors declare no conflict of interest.
References and Notes
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Sample Availability: Samples of the compounds described in the text are not immediately available
from the authors, but may be prepared upon request.
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