A critical structural determinant of opioid receptor interaction with phenolic 5-phenylmorphans.

Article abstract of DOI:10.1016/j.bmc.2004.05.038

The opioid receptor binding affinities of N-methyl- and N-phenethyl-5-phenylmorphans with a meta-hydroxy substituent [3-(2-methyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (1a), and 3-(2-phenethyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (1b)] were compared with the