Estrogen receptor based imaging agents. 1. Synthesis and receptor binding affinity of some aromatic and D-ring halogenated estrogens

Article abstract of DOI:10.1021/jm00183a007

Steroidal and nonsteroidal estrogens substituted with halogens ortho to the phenolic hydroxyl group and in the D ring at C-16 have been prepared as potential estrogen receptor-based imaging agents for human breast tumors. Estrogens bearing an aromatic flu