Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives

Article abstract of DOI:10.1016/j.ejmech.2018.03.048

Human African trypanosomiasis is causing thousands of deaths every year in the rural areas of sub-saharan Africa. There is a high unmet medical need since the approved drugs are poorly efficacious, show considerable toxicity and are not easy to administer