Journal of Medicinal Chemistry p. 2976 - 2981 (1990)
Update date:2022-08-04
Topics:
Engel, Juergen
Fleischhauer, Ilona
Jakovlev, Vladimir
Kleemann, Axel
Kutscher, Bernhard
et al.
In the course of studies on tranquilizers, new non-benzodiazepine-like compounds were synthesized.These are 1-(3,4,5-trimethoxyphenoxy)-3-<4-(2-methoxyphenyl)piperazinyl>propan-2-ol (INN: enciprazine) and derivatives thereof which were screened pharmacologically in order to evaluate their central nervous system activity.Compounds with marked antiaggressive and anxiolytic properties but without dependence potential could be detected.Enciprazine was selected for clinical investigations.
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