New 2-alkylidenemethyl-5-nitrothiophenes: Preparation vis S(RN)1 reactions and in vitro antiprotozoan activity

Article abstract of DOI:10.1016/0223-5234(94)90124-4

The reaction of 2-chloromethyl-5-nitrothiophene with the 2-nitropropane anion has been reinvestigated and extended to various nitronate anions to afford good yields of new 5-nitrothiophenes bearing a trisubstituted ethylenic double bond at the 2-position. These compounds were evaluated as potential antiprotozoan agents and some derivatives were found to have the same activity as that of reference compounds.