New 2-alkylidenemethyl-5-nitrothiophenes: Preparation vis S(RN)1 reactions and in vitro antiprotozoan activity

DOI: 10.1016/0223-5234(94)90124-4

Source and publish data:

European Journal of Medicinal Chemistry p. 41 - 44 (1994)

Update date:2022-08-02

Topics:

Authors:

Vanelle Vanelle

Ghezali Ghezali

Maldonado

Crozet Crozet

Delmas Delmas

Gasquet Gasquet

Timon-David

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Article abstract of DOI:10.1016/0223-5234(94)90124-4

The reaction of 2-chloromethyl-5-nitrothiophene with the 2-nitropropane anion has been reinvestigated and extended to various nitronate anions to afford good yields of new 5-nitrothiophenes bearing a trisubstituted ethylenic double bond at the 2-position. These compounds were evaluated as potential antiprotozoan agents and some derivatives were found to have the same activity as that of reference compounds.

Full text of DOI:10.1016/0223-5234(94)90124-4

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