Structure-Activity Relationships in a Series of Newly Synthesized 1-Amino-Substituted Ellipticine Derivatives

Article abstract of DOI:10.1021/jm00185a012

The synthesis of a series of 1-amino-substituted pyrido<4,3-b>carbazole derivatives, based on the substitution of corresponding 1-chloroellipticines, is reported.The cytotoxic properties on tumor cells grown in vitro, the in vivo acute toxicity of the mos