CHELATION-CONTROLLED NUCLEOPHILIC ADDITIONS. 1. A HIGHLY EFFECTIVE SYSTEM FOR ASYMMETRIC INDUCTION IN THE REACTION OF ORGANOMETALLICS WITH α-ALKOXYKETONES.

Article abstract of DOI:10.1016/S0040-4039(00)78831-9

An optimum reaction system is described for the highly stereoselective addition of carbanionic nucleophiles to chiral α-alkoxyketones.A variety of oxygen protecting groups are acceptable and allow chelation-controlled α-asymmetric induction with diastereo