Tetrahedron p. 1017 - 1021 (1980)
Update date:2022-08-05
Topics:
Orito, Kazuhiko
Matsuzaki, Tsutomu
Alkylation of 1,2,4,5-tetrahydro-3-methyl-3H-3-benzazepin-2-one 1a with various halides and sodium hydride in tetrahydrofuran-dimethylformamide solvent system was studied.Primary halides predominantly provided the 1-mono-substituted products, such as alkyl (2a-g,p,q), allyl (2j,k), propargyl (2l) and benzyl (2m-o) derivatives, in satisfactory yields, and secondary halides resulted in lower yields (2h,i) than primary halides.In attempted dialkylations with ω,ω'-dibromoalkanes, 5- and 6-membered spiro products (4c,d) were obtained by this method.The Michael type addition reaction was also studied and it was found that acrylic acid esters gave the corresponding adducts (2p,q).
View MoreXiamen Kaijia Imp & Exp Co., Ltd.
Contact:86-592-5101177
Address:Room406 Luhui Building No. 65 Haitian Road Huli Xiamen,China.
website:https://www.bocsci.com/
Contact:1-631-485-4226
Address:Ramsey Road
Yangling Ciyuan biotech Co., Ltd.
Contact:86-15802970736
Address:2-1804, International Park Mansion, No.2, South Fengdeng Road, Lianhu District
Feis International Trade Co,. Ltd
Contact:13961823444-18235944442
Address:Wuxi jiangsu
SHENZHEN PENGCHENG REDSTAR INDUSTRY CO.,LTD
Contact:+86-755-82412922
Address:Room 8066, East Block, Square City, Jiabin Road, Luohu District
Doi:10.1021/jo0493370
(2004)Doi:10.1139/cjc-2013-0132
(2013)Doi:10.1039/c3ob40876k
(2013)Doi:10.1039/c3cc44567d
(2013)Doi:10.1002/pola.27058
(2014)Doi:10.1016/j.tet.2013.09.025
(2013)