AN ASYMMETRIC SYNTHESIS OF β-FORMYL β-HYDROXY ESTERS

Article abstract of DOI:10.1246/cl.1980.455

Optically active β-formyl β-hydroxy esters are prepared in high enantiomeric excess by treating 2-acyl-1,3-diazabicyclo<3.3.0>-octane derivatives, prepared from (S)-2-(substituted aminomethyl)-pyrrolidine and phenylglyoxal monohydrate or methyl hydroxymethoxyacetate, with metal enolates of ethyl acetate.