Analogues of chloramphenicol: Circular dichroism spectra, inhibition of ribosomal peptidyltransferase, and possible mechanism of action

Article abstract of DOI:10.1021/jm00186a004

Circular dichroism spectra of a series of chloramphenicol derivatives 1a-r were measured in water at pH 7. Compounds 1a-o exhibit two positive Cotton effects at 310-340 and 240-260 nm, respectively, and a weaker negative Cotton effect at 280-300 nm. In an