Lipophilic and hydrophilic esters of 4-acetyl-2-(2-hydroxyethyl)-5,6-bis (4-chlorophenyl)2h-pyridazin-3-one as antihypertensive agents

Article abstract of DOI:10.1021/jm00186a030

In an attempt to enhance the antihypertensive activity of 4-acetyl-2-(2-hydroxyethyl)-5,6-bis(4-chlorophenyl)-2H-pyridazin-3-one, (1), a series of lipophilic and hydrophilic esters was synthesized. These derivatives possessed increased lipid and aqueous s