Reactions with (Arylmethylene)cycloalkanones. 4. Synthesis of Derivatives of Octahydrocyclooctathiazolopyrimidin-3-one of Expected Biological Activity

Article abstract of DOI:10.1021/je00023a030

Cyclooctapyrimidin-2-thiones (III) were prepared by heating 2-(arylmethylene)cyclooctanones with thiourea in ethanolic potassium hydroxide.Compounds III reacted with chloroacetic acid to yield 2-acetyl-2,3,6,7,8,9,10,11-octahydro-5H-cyclooctathiazolo<3,2-a>pyrimidin-3-ones (IV).The 2-arylmethylene derivatives (V) and the 2-arylhydrazono derivatives VI were prepared.