Journal of Organic Chemistry p. 327 - 330 (1981)
Update date:2022-08-03
Topics:
Bradsher, Charles K.
Hunt, David A.
Reaction of Schiff bases with certain functionalized organolithium reagents is useful in the synthesis of 1,2-diarylisoindolines and 2,3-diarylphthalimidines.Schiff bases derived from 2-(2-bromophenyl)ethylamines on halogen-metal exchange with butyllithium undergo a Parham-type cyclization to yield 1-aryl-1,2,3,4-tetrahydroisoquinolines.
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