Archiv der Pharmazie p. 851 - 858 (1980)
Update date:2022-08-04
Topics:
Teuber, Hans-Joachim
Schuetz, Guenther
Erkenbrecher, Eberhard
The substituted crotonitrile 1a formed by dimerization of chloroacetonitrile is reacted with primary, secondary and tertiary amines.With primary amines the pyrrolines 3a-c result which contain the partial structure of a vinylogous guanidine.Compound 3a is hydrolized by hydrochloric acid to yield the lactam 4 of β,γ-diaminocrotonic acid.
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Doi:10.1021/ja00545a032
(1980)Doi:10.1246/bcsj.53.2281
(1980)Doi:10.1021/jm00362a018
(1983)Doi:10.1021/ja01239a032
(1944)Doi:10.1016/j.tetasy.2004.05.042
(2004)Doi:10.1039/c5ra17994g
(2015)