Quantitative Structure-Activity Relationships of Colchicines against P388 Leukemia in Mice

DOI: 10.1021/jm00135a004

Source and publish data:

Journal of Medicinal Chemistry p. 251 - 256 (1981)

Update date:2022-07-30

Topics: Medicinal chemistry Biological Activity Colchicine Mice

Authors:

Quinn, Frank R.

Beisler, John A.

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Article abstract of DOI:10.1021/jm00135a004

A quantitative structure-activity relationship (QSAR) was derived for colchicine and 14 analogues acting against P388 lymphocytic leukemia in mice.Twelve additional compounds were synthesized to reinforce and confirm the correlation.The final correlation

Full text of DOI:10.1021/jm00135a004

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