Medicinal Chemistry Research p. 518 - 527 (2004)
Update date:2022-08-05
Topics:
Kumar, S.T.V.S. Kiran
Sharma
Srivastava, Shipra
Bhandari, Kalpana
Shander, Girija
Singh
Several 1-(substituted phenoxy)-3-{4-(4-trifluoromethyl) phenoxy] piperidin-1-yl} propan-2-ols (str.II) were prepared in a six-step reaction sequence starting from methylamine and ethyl acrylate and evaluated for antidepressant activity. The compounds were fully characterized by spectral and elemental analyses, and were tested for their effect on gross behavior, antireserpine and anorexigenic activity. No effect was observed on gross behavior and some of them showed fluoxetine like antireserpine and anorexigenic activity. Birkhaeuser Boston 2005.
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