Chemistry of 2-Substituted Pyrimidines. Studies Directed toward the Synthesis of the Pyrimidine Moiety of Bleomycin

Article abstract of DOI:10.1021/jo00320a037

Synthetic approaches to 2-substituted pyrimidines have been studied in an effort to facilitate the preparation of the pyrimidine moiety of bleomycin (2).Ethyl 2,5-dimethyl-4-oxopyrimidine-6-carboxylate (4) has been utilized as starting material; its conve