CESIUM FLUORIDE PROMOTES SYNTHESYS OF RIBOOLIGONUCLEOTIDES VIA PHOSPHOTRIESTER APPROACH

Article abstract of DOI:10.1246/cl.1980.1419

In the presence of cesium fluoride, the reactions of a fully protected 5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N-acylnucleoside 3'-(4-chlorophenyl, 5-chloro-8-quinolyl) phosphates with 5'-hydroxyl nucleosides proceeded rapidly under mild conditions to afford the corresponding ribonucleoside monophosphates in good yields.