Methotrexate Analogues. 13. Chemical and Pharmacological Studies on Amide, Hydrazide, and Hydroxamic Acid Derivatives of the Glutamate Side Chain

DOI: 10.1021/jm00137a016

Source and publish data:

Journal of Medicinal Chemistry p. 559 - 567 (1981)

Update date:2022-08-04

Topics:

Authors:

Rosowsky, Andre

Yu, Cheng-Sein

Uren, Jack

Lazarus, Herbert

Wick, Michael

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Article abstract of DOI:10.1021/jm00137a016

Carbodiimide-mediated condensation of 4-amino-4-deoxy-N¹⁰-methylpteroic acid (APA) with several alkyl, aralkyl, and aryl amines, in the presence or absence of N-hydroxysuccinimide, was employed in order to prepare new lipid-soluble bis(amide) d

Full text of DOI:10.1021/jm00137a016

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