Methotrexate Analogues. 13. Chemical and Pharmacological Studies on Amide, Hydrazide, and Hydroxamic Acid Derivatives of the Glutamate Side Chain

DOI: 10.1021/jm00137a016

Source and publish data:

Journal of Medicinal Chemistry p. 559 - 567 (1981)

Update date:2022-08-04

Topics:

Authors:

Rosowsky, Andre

Yu, Cheng-Sein

Uren, Jack

Lazarus, Herbert

Wick, Michael

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00137a016

Carbodiimide-mediated condensation of 4-amino-4-deoxy-N¹⁰-methylpteroic acid (APA) with several alkyl, aralkyl, and aryl amines, in the presence or absence of N-hydroxysuccinimide, was employed in order to prepare new lipid-soluble bis(amide) d

Full text of DOI:10.1021/jm00137a016

Products guided by the article

Product name:(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid bis-(4-methoxy-benzylamide)

Cas No:77410-24-3

R&D Labs maybe for 77410-24-3

Dongying J&M Chemical Co., Ltd,

Contact:546-8551108

Address:Room 1219, Zisheng Mansion, Zibo Road, Dongying, Shandong, China
Beijing Wisdom Chemicals Co., Ltd.

Contact:+86-10-52350335

Address:F2, BLDG 19, Liando Valley U, Majuqiao, Tongzhou District, Beijing, China
Zhejiang Golden-Shell Pharmaceutical Co.,Ltd.

Contact:+86-576-87501888 / 87501988

Address:No.89 Zhongxing Road. Li'ao, Yuhuan, Zhejiang, China
Hubei Sibo Technology Co.,Ltd.

Contact:0715-6597222

Address:Pan Jia Wan fan Lake Chemical Industrial Park ,Xianning City, Hubei, China
AllyChem Co., Ltd., Dalian, China（BBChem）

Contact:+86-411-62313318/62313328

Address:No.5 of Jinbin Road, Jinzhou New District, Dalian City, Liaoning Province, P.R.China

Relevant to this article

Ring-opening hydroarylation of monosubstituted cyclopropanes enabled by hexafluoroisopropanol

Doi:10.1039/c8sc02126k
(2018)
The first (trisulfoxide)metal complexes: Synthesis and crystal structures of the 1D lanthanide coordination polymers [Ln(L)(MeOH)(NO₃) ₃]_n and {[La(L)(DMF)₅](ClO₄) ₃}_n [L = 1,3,5-tris(ethylsulfinyl)-2,4,6-trimethylbenzene, Ln = La^III and Nd^III]

Doi:10.1002/ejic.200300751
(2004)
THE PREPARATION AND ANTITUMOR PROPERTIES OF ACYLATED DERIVATIVES OF

Doi:10.1021/jm00332a015
(1964)
Synthesis of aza-, oxa-, and thiabicyclo[3.1.0]hexane heterocycles from a common synthetic intermediate

Doi:10.1021/ol050730h
(2005)
Synthesis of the 3-methyl and 4-methyl derivatives of 3-amino-3,4-dihydro-1-hydroxycarbostyril and related compounds

Doi:10.1002/jhet.5570170711
(1980)
A novel synthetic method for optically active terpenes by the ring-opening reaction of (R)-(+)-β-methyl-β-propiolactone

Doi:10.1016/S0040-4039(00)78693-X
(1980)

Article Doi