Bioorganic and Medicinal Chemistry Letters p. 5223 - 5226 (2004)
Update date:2022-07-31
Topics:
Liu, Bo
Liu, Gang
Xin, Zhili
Serby, Micheal D.
Zhao, Hongyu
Schaefer, Verlyn G.
Falls, H. Douglas
Kaszubska, Wiweka
Collins, Christine A.
Sham, Hing L.
Novel isoxazole carboxamides have been identified as growth hormone secretagogue receptor (GHS-R) antagonists. Substituent modification off the 5-position of the isoxazole ring led to analogues with potent binding affinity and functional antagonism of GHS-R. A potent analogue (32) with high aqueous solubility and good GPCR selectivity was also identified as a potential pharmacological tool for in vivo studies.
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Doi:10.1021/acs.joc.5b00771
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(1981)Doi:10.1246/bcsj.59.221
(1986)Doi:10.1007/s10895-013-1294-7
(2014)Doi:10.1021/om0400806
(2004)Doi:10.1515/znb-2002-0402
(2002)
