Synthesis of 3-Aryl-3-pyridylallylamines Related to Zimelidine via Palladium-Catalyzed Amination

DOI: 10.1021/jo00330a019

Source and publish data:

Journal of Organic Chemistry p. 3479 - 3483 (1981)

Update date:2022-08-04

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Authors:

Baeckvall, Jan-E.

Nordberg, Ruth E.

Nystroem, Jan-E.

Hoegberg, Thomas

Ulff, Bengt

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Article abstract of DOI:10.1021/jo00330a019

Reaction of aryl pyridyl ketones 1 with vinylmagnesium bromide followed by acetylation of the products 2 with acetic anhydride/Et3N and with 4-(dimethylamino)pyridine (DMAP) as a catalyst gave acetates 3 in high yields.Treatment of acetates 3 with dimethylamine in the presence of a palladium catalyst produced a mixture of E and Z isomers of 3-aryl-3-pyridylallylamines 4.

Full text of DOI:10.1021/jo00330a019

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