Chemical and Pharmaceutical Bulletin p. 382 - 384 (1994)
Update date:2022-07-29
Topics:
Fujii
Saito
Ii
Suzuki
The Dimroth rearrangement of 7-alkyl-1-methyladenines (8) to produce 7- alkyl-N6-methyladenines (9) (63-72% yield) has been found to be accompanied with unusual hydrolytic deaminations to give 7-alkyl-1-methyl-hypoxanthines (10) (1-3.5%) and/or 7-alkylhypoxanthines (11) (12-22%), when effected in boiling H2O for 4-70 h. Probable pathways leading to these by-products are proposed.
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