A new chiral route to optically pure 3-oxodicyclopentadiene: A versatile chiral cyclopentadienone synthon, via contra-steric Diels-Alder reaction

Article abstract of DOI:10.1055/s-1996-4342

Optically pure oxodicyclopentadiene (KDP) has been prepared in both enantiomeric forms from racemic 4-tert-butoxycyclopent-2-en-1-one in three ways starting from 4-tert-butoxycyclopent-2-en-1-one involving contra-steric Diels-Alder reaction and lipase-mediated enantiospecific kinetic transesterification as key steps.