Silica gel as solid support in the synthesis of oligoribonucleotides

Article abstract of DOI:10.1016/S0040-4039(00)93677-3

A method is described for the synthesis of ribonucleotides using silica gel as a polymer support. Yields were > 85% at each step in the synthesis of a hexanucleotide containing all four common ribonucleosides.