Journal of Medicinal Chemistry p. 1584 - 1597 (2007)
Update date:2022-08-04
Topics:
Dai, Yujia
Hartandi, Kresna
Ji, Zhiqin
Ahmed, Asma A.
Albert, Daniel H.
Bauch, Joy L.
Bouska, Jennifer J.
Bousquet, Peter F.
Cunha, George A.
Glaser, Keith B.
Harris, Christopher M.
Hickman, Dean
Guo, Jun
Li, Junling
Marcotte, Patrick A.
Marsh, Kennan C.
Moskey, Maria D.
Martin, Ruth L.
Olson, Amanda M.
Osterling, Donald J.
Pease, Lori J.
Soni, Niru B.
Stewart, Kent D.
Stoll, Vincent S.
Tapang, Paul
Reuter, David R.
Davidsen, Steven K.
Michaelides, Michael R.
In our continued efforts to search for potent and novel receptor tyrosine kinase (RTK) inhibitors as potential anticancer agents, we discovered, through a structure-based design, that 3-aminoindazole could serve as an efficient hinge-binding template for kinase inhibitors. By incorporating an N,N′-diaryl urea moiety at the C4-position of 3-aminodazole, a series of RTK inhibitors were generated, which potently inhibited the tyrosine kinase activity of the vascular endothelial growth factor receptor and the platelet-derived growth factor receptor families. A number of compounds with potent oral activity were identified by utilizing an estradiol-induced mouse uterine edema model and an HT1080 human fibrosarcoma xenograft tumor model. In particular, compound 17p (ABT-869) was found to possess favorable pharmacokinetic profiles across different species and display significant tumor growth inhibition in multiple preclinical animal models.
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