A SIMPLE NEW GENERAL SYNTHESIS OF MACROCYCLIC KETONES: A NEW ENTRY TO THE SYNTHESIS OF EXALTONE AND (+/-)-MUSCONE

Article abstract of DOI:10.1016/S0040-4039(00)96432-3

We describe an efficient new synthesis of 15-membered cyclic ketones, exaltone and (+/-)-muscone, based on a three-carbon annelation of cyclic ketones followed by the regioselective radical cleavage of the fused bond of the resulting bicyclic systems.