Organic Process Research and Development p. 255 - 262 (2009)
Update date:2022-07-30
Topics:
Yates, Matthew H.
Kallman, Neil J.
Ley, Christopher P.
Wei, Jeffrey N.
The synthesis of 5-bromo-thiophene-2-sulfonic acid 2,4-dichlo- robenzoylamide sodium salt on multikilogram scale is described. The initial clinical supplies were made using carbonyl diimidazole to converge the two fragments. A more efficient acid chloride process has been developed, which also provides better control of impurities and color throughout the synthesis.
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