EFFICIENT STEREOSELECTIVE SYNTHESIS OF rel-(6S,7S,8S)-7-BUTYL-8-HYDROXY-1-AZASPIROUNDECAN-2-ONE, A KEY INTERMEDIATE FOR PERHYDROHISTRIONICOTOXIN, AND ITS rel-(6R) ISOMER

DOI: 10.1246/cl.1981.1409

Source and publish data:

Chemistry Letters p. 1409 - 1412 (1981)

Update date:2022-09-26

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Authors:

Ibuka, Toshiro

Minakata, Hiroyuki

Mitsui, Yoshinori

Tabushi, Eiji

Taga, Tooru

Inubushi, Yasuo

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Article abstract of DOI:10.1246/cl.1981.1409

Using 3-t-butyldimethylsilyloxy-1-cyclohexenyl methyl ketone as a starting material, a simple stereoselective synthesis of rel-(6S,7S,8S)-7-butyl-8-hydroxy-1-azaspiro<5.5>undecan-2-one, a useful intermediate for the synthesis of pharmacologically importan

Full text of DOI:10.1246/cl.1981.1409

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