Tetrahedron p. 2509 - 2514 (1981)
Update date:2022-08-04
Topics:
Bilton, R. F.
Mason, A. N.
Tenneson, M. E.
Minor products in the microbial degradation of deoxychlolic acid are characterised and a metabolic pathway proposed.In a previous publocation we reported the transformation of deoxycholic acid 1 by Pseudomonas sp.NCIB 10590, in a mineral salts medium, to a mixture of neutral and acidic steroids.The major neutral product, 12β-hydroxyandrosta-1,4-dien-3,17-dione 2 and the major acidic product 12α-hydroxypregna-1,4-dien-3-one-20-carboxylic acid 9 were identified.We now report the structures of the minor products and propose a metabolic pathway.
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