Lysine and Ornithine Analogues of Methotrexate as Inhibitors of Dihydrofolate Reductase

DOI: 10.1021/jm00346a026

Source and publish data:

Journal of Medicinal Chemistry p. 475 - 477 (1982)

Update date:2022-08-03

Topics: Inhibitors Analogues Lysine Methotrexate Dihydrofolate reductase

Authors:

Kempton, Robert J.

Black, Angelique M.

Anstead, Gregory M.

Kumar, A. Ashok

Blankenship, Dale T.

Freisheim, James H.

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Article abstract of DOI:10.1021/jm00346a026

The ornithine (6a) and lysine (6b) analogues of methotrexate (1) have been synthesized via condensation of 4-amino-4-deoxy-N¹⁰-methylpteroic acid (2) with N^δ-carbobenzoxy-L-ornithine tert-butyl ester (3a) and N^ε-carbobenzo

Full text of DOI:10.1021/jm00346a026

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