Lysine and Ornithine Analogues of Methotrexate as Inhibitors of Dihydrofolate Reductase

DOI: 10.1021/jm00346a026

Source and publish data:

Journal of Medicinal Chemistry p. 475 - 477 (1982)

Update date:2022-08-03

Topics: Inhibitors Analogues Lysine Methotrexate Dihydrofolate reductase

Authors:

Kempton, Robert J.

Black, Angelique M.

Anstead, Gregory M.

Kumar, A. Ashok

Blankenship, Dale T.

Freisheim, James H.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00346a026

The ornithine (6a) and lysine (6b) analogues of methotrexate (1) have been synthesized via condensation of 4-amino-4-deoxy-N¹⁰-methylpteroic acid (2) with N^δ-carbobenzoxy-L-ornithine tert-butyl ester (3a) and N^ε-carbobenzo

Full text of DOI:10.1021/jm00346a026

Products guided by the article

Product name:N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine tert-butyl ester

Cas No:80407-75-6

R&D Labs maybe for 80407-75-6

Beijing Mesochem Technology Co.,LTD

website:http://www.mesochem.com

Contact:0086-10-57862036

Address:2301, Floor 23, Building 9 Lippo Plaza, Yard 8 Ronghua Middle Road, ETDZ, Beijing, China
zhenjiang runjing high purity chemical co ltd

Contact:+86-511-83361155

Address:No.8.haixi road,international chemical park
nanjing suru chemical co.ltd

Contact:+86-025-52406782

Address:8 Taizishan Rd., Yanjiang Industrial Development Area, Nanjing, Jiangsu, China.
SHANGHAI RC CHEMICALS CO.,LTD.

website:http://www.rcc.net.cn

Contact:+86-21-50322175

Address:Rm1415 Yinqiao Masion No.58 Jinxin Road Pudong Shanghai China
HANGZHOU PANYU CHEMICAL CO.,LIMITED

Contact:+86-571-86578491

Address:Rm 605, NO.1870 Binsheng Road,Binjiang Dist, Hangzhou, China

Relevant to this article

α-FLUOROALKYLAMINES - A NEW SOURCE OF THE UNHYDRATED FLUORIDE ION. 4. ACYLATION OF PERFLUOROALKYL CARBANIONS WITH THE FLUOROANHYDRIDES OF CARBOXYLIC ACIDS

Doi:10.1007/BF00963424
(1981)
Stereochemistry of Substitution of Good Nucleofuges at the Stereoconvergence Region as a Tool for Investigating the Rapid Step of Nucleophilic Vinylic Substitution

Doi:10.1021/ja00211a035
(1988)
Potential inhibitors of nucleotide biosynthesis. 2. Halomethyl ketone derivatives of pyrimidine nucleosides

Doi:10.1021/jm00371a022
(1984)
NMR of enaminones: Part 4 - ¹⁷O NMR study of 2,2-diacylenamines

Doi:10.1002/(SICI)1097-458X(199707)35:7<432::AID-OMR107>3.0.CO;2-F
(1997)
Synthesis and characterization of some ruthenium-phosphoniodithiocarboxylate complexes

Doi:10.1021/ic00135a067
(1982)
Studies related to biological detoxification of Kraft pulp mill effluent. II. The biotransformation of isopimaric acid with Mortierella isabellina

Doi:10.1139/v81-497
(1981)

Article Doi