
Helvetica Chimica Acta p. 2279 - 2297 (1981)
Update date:2022-08-04
Topics:
Heinzer, Franz
Bellus, Daniel
A versatile new synthetic pathway for the preparation of β,γ-unsaturated α-amino acids (1) is presented.Cu(I)-catalyzed addition of ethyl isocyanoacetate (2) to α-chloro carbonyl compounds (3) gives 5-chloroalkyl-2-oxazolin-4-carboxylates (4) in high yiel
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(1985)