SYNTHESIS OF FUNCTIONALIZED DIAZA(2,5)PYRIDINOPHANES

Article abstract of DOI:10.1246/cl.1981.1749

A general synthetic method of N²,N⁽ⁿ⁺³⁾-di-p-toluenesulfonyl-(n+9)-hydroxy-(n+10)-hydroxymethyl-(n+9),(n+10)'-O-isopropylidene-2,(n+3)-diaza(2,5)pyridinophanes was established by the reaction of 5'-deoxy-2',5'-dichloro-3,4'-O-isopropylidenepyridoxine hydrochloride with N,N'-di-p-toluenesulfonyl-α,ω-alkanediamine disodium salt in N,N-dimethylformamide at 70-90 deg C in fairly good yield depending on the chain length.