New constrained "molecular tongs" designed to dissociate HIV-1 protease dimer

DOI: 10.1021/jm040833q

Source and publish data:

Journal of Medicinal Chemistry p. 6392 - 6400 (2004)

Update date:2022-08-03

Topics:

Authors:

Merabet, Naima

Dumond, Julien

Collinet, Bruno

Van Baelinghem, Laurence

Boggetto, Nicole

Ongeri, Sandrine

Ressad, Fariza

Reboud-Ravaux, Michèle

Sicsic, Sames

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Article abstract of DOI:10.1021/jm040833q

New "molecular tongs" based on naphthalene and quinoline scaffolds linked to two peptidic strands were synthesized. They were designed to prevent dimerization of HIV-1 protease by targeting the antiparallel β-sheet involving N- and C-termini of each monom

Full text of DOI:10.1021/jm040833q

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