
Chemistry of Heterocyclic Compounds p. 100 - 102 (1982)
Update date:2022-08-04
Topics:
Melik-Ogandzhanyan, R. G.
Gapoyan, A. S.
Khachatryan, V. E.
Mirzoyan, V. S.
A new scheme was developed for the synthesis of 2,4-dimethyl-5,6-dihydro-6-bromomethylthieno<2,3-d>pyrimidine by bromination of the corresponding 5-allyl-6-mercaptopyrimidine.It is shown that when the bromomethyl derivative is treated with sodium methoxide a molecule of hydrogen bromide is split out to give 2,4,6-trimethylthieno<2,3-d>pyrimidine.The structures of the synthesized compounds were proved by PMR spectroscopy and mass spectrometry.
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