Regioselective Functionalization of 4-Methyl-1H-indole for Scalable Synthesis of 2-Cyano-5-formyl-4-methyl-1H-indole

DOI: 10.1021/acs.oprd.7b00370

Source and publish data:

Organic Process Research and Development p. 97 - 102 (2018)

Update date:2022-09-26

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Authors:

Zhang, Jun

Hu, Yun Hu, Yun

Wang, Haiyu

Guo, Aixin

Kong, Jianshe

Ma, Rujian

Wu, Tao Wu, Tao

Wang, Yi

Li, Lian-Sheng

Mai, Wanping

Ren, Pingda

Deng, Xiaohu

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Article abstract of DOI:10.1021/acs.oprd.7b00370

We report a five-step synthesis of 2-cyano-5-formyl-4-methyl-1H-indole through sequential functionalization of readily available 4-methyl-1H-indole. Cyano and aldehyde functionalities are regioselectively installed at the 2 and 5 position, respectively. T

Full text of DOI:10.1021/acs.oprd.7b00370

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