SYNTHESIS OF THE RIBOSIDE ANALOG OF THE PYRIMIDINE ADDUCT FORMED IN THE REACTION BETWEEN THE CARCINOGEN N-HYDROXY-N-2 ACETYLAMINOFLUORENE AND DNA

Article abstract of DOI:10.1016/S0040-4039(00)98129-2

A general synthesis has been achieved to obtain carcinogen modified guanosines.The method was applied to the preparation of the N-2,5-diamino-4-oxo-3H-pyrimidine-6-yl-N-(β-D-ribofuranosyl)-N'-(2-fluorenyl)urea 6.