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Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead

DOI: 10.1016/j.bmcl.2006.02.051

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2595 - 2598 (2006)

Update date:2022-08-05

Topics:

Authors:

Williams, Theresa M.Williams, Theresa M.

Stump, Craig A.Stump, Craig A.

Nguyen, Diem N.Nguyen, Diem N.

Quigley, Amy G.Quigley, Amy G.

Bell, Ian M.Bell, Ian M.

Gallicchio, Steven N.Gallicchio, Steven N.

Zartman, C. BlairZartman, C. Blair

Wan, Bang-LinWan, Bang-Lin

Penna, Kimberly DellaPenna, Kimberly Della

Kunapuli, PriyaKunapuli, Priya

Kane, Stefanie A.Kane, Stefanie A.

Koblan, Ken S.Koblan, Ken S.

Mosser, Scott D.Mosser, Scott D.

Rutledge, Ruth Z.Rutledge, Ruth Z.

Salvatore, ChristopherSalvatore, Christopher

Fay, John F.Fay, John F.

Vacca, Joseph P.Vacca, Joseph P.

Graham, Samuel L.Graham, Samuel L.

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Article abstract of DOI:10.1016/j.bmcl.2006.02.051

High-throughput screening of the Merck sample collection identified benzodiazepinone tetralin-spirohydantoin 1 as a CGRP receptor antagonist with micromolar activity. Comparing the structure of 1 with those of earlier peptide-based antagonists such as BIB

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Full text of DOI:10.1016/j.bmcl.2006.02.051

Products guided by the article

Product name:1-Piperidinecarboxamide, N-[2,3-dihydro-1-(1-methylethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin- 3-yl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-

Cas No:820214-30-0

820214-30-0

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