Journal of Medicinal Chemistry p. 983 - 986 (1982)
Update date:2022-08-05
Topics:
Quick
Herlihy
Razdan
Howes
A series of 7-alkanoyl-substituted hydromorphone derivatives were prepared by acylation of the morpholine enamines. The most potent compound (6i) of the series was found to have agonist activity of the same order of magnitude as that of buprenorphine. The N-cyclopropylmethyl-substituted series was found to exhibit structure-activity relationships for analgesia and narcotic antagonism similar to those of the endo-ethanotetrahydrooripavines.
View MoreHK Vast Medicinal Chemistry Int'l Group Limited(expird)
website:http://www.hkvast.com/
Contact:+86-15000309979
Address:NO.6,Lane 108,Qinzhou Road,Xuhui District,Shanghai
Contact:86-574-26865651
Address:529 YuanBaoShan Road, Beilun District
Contact:86-571-87758773
Address:Room604 ,6F, Block A1-3 Xixi Plaza,No. 588 Wenyi West RD, Hangzhou,310012, China
website:http://www.greenutra.cn
Contact:0086-411-39553357
Address:No. 7-1-1802, Huizhi Garden,Ocean Square,Dalian, 116033, China
Shijiazhuang Sdyano Fine Chemical Co., Ltd
Contact:+86-311-89830448
Address:NO.48 Ta Nan Road,Yuhua District,Shijiazhuang,Hebei,China
Doi:10.1021/ja045416h
(2004)Doi:10.1021/jm00352a008
(1982)Doi:10.1246/bcsj.55.1673
(1982)Doi:10.1016/j.saa.2004.02.035
(2005)Doi:10.1039/b412323a
(2004)Doi:10.1016/j.tetlet.2004.10.122
(2004)
