SYNTHESIS OF DES-N-TETRAMETHYLTRIOSTIN A FROM C-TERMINAL Z-D-SERINE TETRA- AND OCTADEPSIPEPTIDE INTERMEDIATES

Article abstract of DOI:10.1016/0040-4020(82)85045-X

Des-N-tetramethyltriostin A (1), a known DNA-intercalation agent, has been synthesized from tetra- and octapeptide intermediates that have Z-D-serine at the C-terminal position.The procedure thus allows the fragment coupling and cyclization reactions lead