Synthesis of 7-thiaprostaglandin E1 congeners: Potent inhibitors of platelet aggregation

DOI: 10.1248/cpb.33.2359

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2359 - 2385 (1985)

Update date:2022-08-02

Topics: Synthesis Congeners Potent Inhibitors Platelet aggregation

Authors:

Tanaka Tanaka

Okamura Okamura

Bannai Bannai

Hazato Hazato

Sugiura Sugiura

Manabe Manabe

Kamimoto

Kurozumi

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Article abstract of DOI:10.1248/cpb.33.2359

Novel 7-thiaprostaglandin E₁ derivatives and congeners were synthesized by a stepwise three-component coupling process, which involves the introduction of α-side chains (thiols) and β-side chains (organocopper reagents) into (R)-4-tert-butyldim

Full text of DOI:10.1248/cpb.33.2359

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