Derivatives of Barbituric Acid, XXX: Synthesis of Racemic and Optically Active Barbituric Acids Carrying Basic Substituents

Article abstract of DOI:10.1002/ardp.19823150810

Monoalkylated malonates were condensed with N-monosubstituted ureas to yield the 5-monosubstituted barbituric acids 1, which were reacted to the 5-bromobarbituric acids 2.From 2 the barbituric acids 3-5 having basic substituents were obtained by nucleophi