PENICILLIN-CEPHALOSPORIN CONVERSION IV. DIRECT SYNTHESIS OF 3'-THIOSUBSTITUTED CEPHALOSPORINS FROM THIAZOLE-AZETIDINONES

DOI: 10.1016/S0040-4039(00)87378-5

Source and publish data:

Tetrahedron Letters p. 2495 - 2498 (1982)

Update date:2022-08-05

Topics:

Authors:

Torii, Sigeru

Tanaka, Hideo

Sasaoka, Michio

Saitoh, Norio

Siroi, Takashi

Nokami, Junzo

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Article abstract of DOI:10.1016/S0040-4039(00)87378-5

Direct transformation of thiazoline-azetidinones 2, derived from penicillin G and V, into 3'-thio-substituted cephalosporins 4 has been performed by ring opening of the thiazoline moiety with sulfenyl chlorides followed by ring closure with NH3 in dimethy

Full text of DOI:10.1016/S0040-4039(00)87378-5

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