Journal of Organic Chemistry p. 4937 - 4940 (1982)
Update date:2022-09-26
Topics:
Takaku, Hiroshi
Kamaike, Kazuo
Kasuga, Kenichi
A new phosphorylating agent, bis(5-chloro-8-quinolyl) phosphate was found to be a useful agent for the phosphorylation of the 5'-hydroxyl group of unprotected nucleosides.This agent smoothly reacts with 3',5',-unprotected nucleosides in the presence of 8-quinolinesulfonyl tetrazolide (QS-t) to give the corresponding bis(5-chloro-8-quinolyl) nucleoside 5'-phosphates in good yields without 3'-mono- and 3',5'-diphosphorylated products.They are key intermediates for the synthesis of oligoribonucleotides bearing 5'-terminal phosphate.Zinc chloride can be used as an effective and mild agent for removal of 5-chloro-8-quinolyl group.
View MoreKangZhiYuan Pharmaceutical Company Limited
Contact:(Sabrina)86-20-85273232
Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China
Contact:+ 86 512 52491118
Address:1 Fuyu Road, Haiyu TownChangshu, Jiangsu, China
Shanghai Coupling Pharmaceutical R&D Co., Ltd.(expird)
Contact:+86 021 50106671
Address:403 Room No.4 Buiding, No. 526 Ruiqing Road, Shanghai Zhangjiang Hi-Tech Park
Changsha Huajing Powdery Material Technological Co., Ltd.
Contact:86-731-88879686
Address:Building 2, West Garden, Main Campus of Central South University, Changsha, Hunan Province, China
Nanjing Capatue Chemical Co., Ltd
Contact:+86-25-86371192 +86-025-85720158
Address:No.20 Jiangjun Avenue, Jiangning Economic & Technical Development Zone
Doi:10.1002/asia.201402323
(2014)Doi:10.1021/jm00355a017
(1983)Doi:10.1021/jo00148a027
(1982)Doi:10.1021/jm040873u
(2005)Doi:10.1039/c5ob02229k
(2016)Doi:10.1039/c6md00234j
(2016)