ELECTROPHILIC AMINATION OF ACYL ANION EQUIVALENTS: MILD OXIDATION OF ALDEHYDES TO AMIDES VIA O-(TRIMETHYLSILYL)ALDEHYDE CYANOHYDRIN ANIONS

Article abstract of DOI:10.1016/S0040-4039(00)87584-X

The O-(trimethylsilyl)aldehyde cyanohydrin anions 4a-p(1-)*Li(1+) react with 5 to the amines 6.This electrophilic amination corresponds to a mild and specific oxidation of the aldehydes 1a-p to the amides 7a-p.